Author

Christopher R. Chang

Gladstone InstitutesORCID 0000-0003-3124-8773Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Organism:human· 2 Research Focus:cancer & tumor microenvironment· 1 Assay:CRISPR screen· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Research Focus:gene regulatory network inference· 1 Approach:genetic perturbation / CRISPR· 1 Research Focus:variant calling· 1

Frequent Co-Authors

Alexander MarsoniD· 2 shared Allison Grace RothrockiD· 2 shared Chang LiuiD· 2 shared Joseph J. MuldooniD· 2 shared Justin EyquemiD· 2 shared Vincent AllainiD· 2 shared William A. NybergiD· 2 shared Alexis TalbotiD· 1 shared

Activity by Year

2024-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersImmunology

Alexander MarsonORCID

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2 papers

Recent·Most cited

ImmunologybioRxivPreprintOct 5, 2025

Site-specific genome engineering of primary human natural killer cells for programmable anti-tumor function

Vincent Allain, Allison Grace Rothrock, Pierre-Louis Bernard…·Justin Eyquem

This paper develops a genome engineering workflow for primary human NK cells using CRISPR/Cas9 and AAV6 to integrate and disrupt genes, enhancing anti-tumor function through targeted CAR expression.

DOI 10.1101/2025.10.05.680386

humangenetic perturbation / CRISPR

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Synthetic BiologybioRxivPreprintFeb 6, 2024

Ultra-high efficiency T cell reprogramming at multiple loci with SEED-Selection

Christopher R. Chang, Vivasvan S. Vykunta, Daniel Bryan Goodman…·Justin Eyquem

This paper develops a method to efficiently reprogram T cells at multiple loci using SEED-Selection, achieving high purity for single and combined gene edits.

1 citation

humanCRISPR screen

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