Author
Friedrich Miescher InstituteORCID 0000-0003-3927-2559Unclaimed ORCID profile · follow to get notified of new preprints
6 papers
Recent·Most cited
Ryan Lusby, Debojyoti Chowdhury, Sarah H. Carl, Vijay Kumar Tiwari
The paper identifies a multi-cancer gene expression signature of brain metastasis using scRNA-seq and neural networks, detectable in blood-derived platelets.
Rajani Kanth Gudipati, Kathrin Braun, Foivos Gypas…·Helge Großhans
The paper shows that proteolytic processing of Argonaute proteins by DPF-3 regulates small RNA association, maintaining genome integrity and fertility in C. elegans.
Sarah H. Carl, Lea Duempelmann, Yukiko Shimada, Marc Bühler
The paper develops an automated deep learning pipeline to segment and classify yeast colonies, achieving 100x faster quantification than manual methods.
Giuditta Annibaldis, René Dreos, Michal Domanski…·Oliver Mühlemann
This study shows that ABCE1 depletion inhibits NMD by promoting stop codon readthrough, which displaces NMD factors from the 3' UTR.
Giovanna Brancati, Sarah H. Carl, Helge Großhans
The paper shows that miRNA activity and specificity depend on both target site architecture and miRNA abundance, challenging the binary view of target site functionality.
Jelena Aleksic, Sarah Carl, Michaela Frye
The paper reviews normalization methods for NGS data, highlighting their impact on differential expression and ChIP-seq results and recommending best practices based on experimental design.