Author

Harry Wischnewski

ETH Zurich

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Genomics· 1 Molecular Biology· 1 Systems Biology· 1

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 2 Research Focus:differential expression· 2 Approach:experimental assay· 2 Approach:statistical model· 2 Organism:human· 1 Organism:mouse· 1 Assay:protein structure· 1 Research Focus:protein structure prediction· 1

Frequent Co-Authors

Constance CiaudoiD· 3 shared Rajika AroraiD· 2 shared Adriano BiasiniiD· 1 shared Amena NabihiD· 1 shared Ana Claudia MarquesiD· 1 shared Baroj AbdulkarimiD· 1 shared Christine von Schroetter· 1 shared Daniel SpiesiD· 1 shared

Activity by Year

2020-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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3 shared papersMolecular Biology

Constance CiaudoORCID

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3 papers

Recent·Most cited

The solution structure of Dead End bound to AU-rich RNA reveals an unprecedented mode of tandem RRM-RNA recognition required for mRNA regulation

Małgorzata Duszczyk, Harry Wischnewski, Tamara Kazeeva, Rajika Arora, Fionna E. Loughlin, Christine von Schroetter, Ugo Pradère, Jonathan Hall, Constance Ciaudo, Frédéric H.‐T. Allain

This study determines the solution structure of DND1 bound to AU-rich RNA, revealing a novel tandem RRM-RNA recognition mechanism essential for mRNA regulation.

Nature Communications · Oct 6, 2022Peer-reviewedMolecular Biology

Integrative analysis allows a global and precise identification of functional miRNA target genes in mESCs

Moritz Schäfer, Amena Nabih, Daniel Spies, Maxime Bodak, Harry Wischnewski, Patrick Stalder, Richard Patryk Ngondo, Luz Angélica Liechti, Tatjana Sajic, Ruedi H. Aebersold, David Gatfield, Constance Ciaudo

The paper identifies that only 6% of expressed genes are functionally regulated by miRNAs in mESCs using integrative analysis of transcriptome data and miRNA interaction predictions.

bioRxiv · Sep 24, 2021 · PreprintSystems Biology

Translation is required for miRNA-dependent decay of endogenous transcripts.

Adriano Biasini, Baroj Abdulkarim, Stefano de Pretis, Jennifer Y. Tan, Rajika Arora, Harry Wischnewski, René Dreos, Mattia Pelizzola, Constance Ciaudo, Ana Claudia Marques

The paper shows that translation is required for miRNA-dependent transcript decay, as non-translated lncRNAs are minimally affected by miRNA loss, while translated transcripts are destabilized.

The EMBO Journal · Dec 10, 2020Peer-reviewedGenomics