Yousheng Shu

Mid-infrared light produces anti-ageing effects through resonant absorption by living organisms

This study shows that mid-infrared light at 34 THz extends the lifespan of C. elegans by 60% through enhancing cellular efficiency, not by thermal effects or stress response activation.

Fos labels a distinct excitatory neuron ensemble for memory retrieval

This study shows that Fos labels excitatory neurons specific for memory retrieval, not those activated during memory encoding.

Multimodal single-cell analyses reveal molecular markers of neuronal senescence in human drug-resistant epilepsy

Axo-axonic synaptic input drives homeostatic plasticity by tuning the axon initial segment structurally and functionally

The paper shows that GABAergic input from chandelier cells tunes the axon initial segment of pyramidal neurons to maintain homeostatic plasticity.

Calneuron 1 reveals the pivotal roles in schizophrenia via perturbing human forebrain development and causing hallucination-like behavior in mice

The paper identifies CALN1 as a key schizophrenia gene by showing its role in disrupting forebrain development and causing hallucination-like behavior in mice.

Structural and functional specializations of human fast spiking neurons support fast cortical signaling

The paper identifies structural and functional adaptations in human fast spiking neurons that enable fast inhibition despite increased cortical distances.

Microglia facilitate and stabilize the response to general anesthesia

This study shows that microglia facilitate and stabilize the general anesthesia response by activating P2Y12 and calcium influx, without involving dendritic spine plasticity.

Prominent contributions of selective neuronal subtypes to pediatric drug-resistant focal dysplasia

The paper identifies specific neuronal subtypes in pediatric FCD that show significant transcriptomic alterations linked to drug-resistant epilepsy and suggests potential therapeutic targets.

The h-current controls cortical recurrent network activity through modulation of dendrosomatic communication

This study shows that reducing the h-current in pyramidal cells increases recurrent network activity and alters dendrosomatic communication.

Functional autapses form in striatal parvalbumin interneurons but not medium spiny neurons

The paper identifies functional autapses in striatal parvalbumin interneurons but not in medium spiny neurons through electrophysiological recordings and simulations.

Single-cell in vivo brain optogenetic stimulation by two-photon excitation fluorescence transfer

This paper introduces a method to enhance two-photon optogenetic stimulation in live mouse brains by using fluorescent molecules to improve opsin activation efficiency.