Michele Alves‐Bezerra

This study encapsulates AAVs into protein vault nanoparticles to bypass neutralizing antibodies, enabling effective gene therapy despite preexisting immunity.

This paper maps the tissue tropism of ten AAV serotypes in mice after systemic delivery, identifying liver preference and unexpected transduction in adrenals, testes, and ovaries.

This paper introduces a novel gene therapy platform using covalently linked adenovirus-AAV complexes to improve co-infection efficiency and reduce AAV dose requirements.

This study shows that deleting Them2 in skeletal muscle reduces weight gain and improves glucose homeostasis on a high-fat diet, but does not prevent hepatic steatosis.