William M. Old

eIF3d and eIF3e mediate selective translational control of hypoxia that can be inhibited by novel small molecules

The paper identifies eIF3d and eIF3e as mediators of hypoxia-induced translational control and shows that small molecules can inhibit this process.

Multi-Omic Analysis Reveals Cannabidiol Disruption of Cholesterol Homeostasis in Human Cell Lines

This study shows CBD disrupts cholesterol homeostasis in human cell lines, altering metabolites, transcripts, and proteins related to cholesterol biosynthesis, transport, and storage.

Proteomic analysis of microtubule inner proteins (MIPs) in Rib72 null Tetrahymena cells reveals functional MIPs

The paper identifies and functionally characterizes MIPs lost in RIB72A/B knockout Tetrahymena cells using proteomics and cryo-electron tomography.

The nuclear interactome of DYRK1A reveals a functional role in DNA damage repair

The paper identifies nuclear interactors of DYRK1A, revealing its role in DNA damage repair and providing a resource for further functional studies.

Cerebral organoid proteomics reveals signatures of dysregulated cortical development associated with human trisomy 21

This study uses cerebral organoid proteomics to identify dysregulated networks in trisomy 21 and shows harmine partially normalizes key developmental regulators.

Identification of the primary peptide inhibitor contaminant of fibrillation and toxicity in synthetic Amyloid-β42

The paper identifies a contaminant peptide in synthetic Amyloid-β42 that inhibits cytotoxicity and fibrillation.

Unexpected Early Proteomic Changes in Alzheimer’s Disease Model Mice Synaptosomes

The paper uses proteomics to identify early changes in AD model mice synaptosomes, finding significant proteomic alterations before traditional disease markers appear.