Adele M. Taylor

This paper evaluates methods to estimate lifetime brain atrophy from a single MRI scan and identifies genetic correlates, finding that the residual method best captures brain shrinkage and has strong heritability.

The paper develops epigenetic scores for GDF15 and NT-proBNP levels, showing associations with disease risks and brain health traits in two cohorts.

The paper identifies general and specific patterns of cortical gene expression related to cognitive functioning using principal component analysis and validates them across datasets.

This study compares DNA methylation signatures of ageing and inflammation in blood and brain tissues, finding divergent correlations and a link between epigenetic age acceleration and microglial burdens in the hippocampus.

The paper applies blood-derived epigenetic predictors of lifestyle traits to brain samples, finding variable correlations across brain regions and a strong link between smoking and the dorsolateral prefrontal cortex.

This study identifies three dimensions of cortical ageing in the human brain and links the most general dimension to cognitive decline across multiple domains in older adults.

The paper quantifies perivascular spaces (PVS) in brain MRI and links them to retinal microvascular parameters in older adults, finding associations with arteriolar narrowing and reduced branching complexity.

This paper introduces DNAm GrimAge, an epigenetic clock that predicts mortality and is associated with multiple brain health measures in older adults.

This study examines how DNAm PhenoAge, a biomarker of biological ageing, relates to health outcomes and cognitive ability across the lifespan, finding that early-life cognitive factors influence later-life health.

This study uses polygenic scores to predict cognitive ability at age 70 and cognitive change from 70 to 79, finding limited predictive validity compared to APOE e4.

The paper matches 73- and 92-year-olds for childhood intelligence, social background, and brain size, finding significant structural brain differences linked to cognitive decline.