Janie Corley

The paper shows that general cognitive function is supported by a widespread white matter network across multiple brain regions and connectivity measures.

This paper evaluates methods to estimate lifetime brain atrophy from a single MRI scan and identifies genetic correlates, finding that the residual method best captures brain shrinkage and has strong heritability.

The paper introduces a weighted 2D-kernel density estimation method for epigenetic age prediction, achieving similar accuracy to existing clocks and providing variation scores linked to mortality risk.

The paper conducts a Bayesian EWAS and GWAS of smoking using DNA methylation data from blood and brain tissues, identifying smoking-related loci and developing an epigenetic biomarker.

The paper identifies brain regions most related to general cognitive function and links them to neurobiological properties using meta-analysis and multimodal cortical maps.

The paper develops epigenetic scores for GDF15 and NT-proBNP levels, showing associations with disease risks and brain health traits in two cohorts.

The paper shows that imputing DNA methylation loci from epigenome-wide data provides stronger associations with smoking and age than directly measured CpGs.

The paper introduces MAJA, a method for joint association testing in multi-omics data, finding shared epigenetic pathways across multiple traits in methylation data.

The paper identifies general and specific patterns of cortical gene expression related to cognitive functioning using principal component analysis and validates them across datasets.

This paper develops an epigenetic score to objectively measure alcohol consumption using blood-based DNA methylation and validates it across multiple cohorts, finding associations with brain health metrics.

This study identifies three dimensions of cortical ageing in the human brain and links the most general dimension to cognitive decline across multiple domains in older adults.

This study identifies lipid biomarkers associated with brain structure but not cognitive ability in older adults using metabolomic data from the LBC1936 cohort.

This paper introduces DNAm GrimAge, an epigenetic clock that predicts mortality and is associated with multiple brain health measures in older adults.

This study identifies neurology-related proteins in plasma associated with cognitive ability and brain volume in older adults, with partial mediation by brain volume.

This study uses polygenic scores to predict cognitive ability at age 70 and cognitive change from 70 to 79, finding limited predictive validity compared to APOE e4.

This study identifies 99 genetic loci associated with general cognitive function using data from 280,360 individuals, finding genes linked to brain structure and neurodegenerative disorders.

The paper matches 73- and 92-year-olds for childhood intelligence, social background, and brain size, finding significant structural brain differences linked to cognitive decline.