Paul H. Redmond

General cognitive function and the brain's structural connectome

The paper shows that general cognitive function is supported by a widespread white matter network across multiple brain regions and connectivity measures.

Lifetime brain atrophy estimated from a single MRI: measurement characteristics and genome-wide correlates

This paper evaluates methods to estimate lifetime brain atrophy from a single MRI scan and identifies genetic correlates, finding that the residual method best captures brain shrinkage and has strong heritability.

Effects of gene dosage on cognitive ability: A function-based association study across brain and non-brain processes

The paper identifies a CNV duplication associated with higher cognitive ability and shows gene-dosage effects differ between deletions and duplications across biological processes.

Copy-number variants and polygenic risk for intelligence confer risk for autism spectrum disorder irrespective of their effects on cognitive ability

This study shows that rare CNVs and PRS-IQ increase ASD risk independently of their effects on cognitive ability, suggesting ASD risk and cognitive ability are distinct outcomes of these variants.

General and specific patterns of cortical gene expression as substrates of complex cognitive functioning

The paper identifies general and specific patterns of cortical gene expression related to cognitive functioning using principal component analysis and validates them across datasets.

Genome-wide analysis identifies genetic effects on reproductive success and ongoing natural selection at the FADS locus.

This study identifies 43 genomic loci associated with reproductive success in 785,604 individuals, showing ongoing natural selection at the FADS locus.

Epigenetic predictors of lifestyle traits applied to the blood and brain

The paper applies blood-derived epigenetic predictors of lifestyle traits to brain samples, finding variable correlations across brain regions and a strong link between smoking and the dorsolateral prefrontal cortex.

Genome wide analysis of gene dosage in 24,092 individuals shows that 10,000 genes modulate cognitive ability

The paper quantifies the effect of copy number variants on cognitive ability using genomic data from 24,092 individuals, finding that 10,000 genes modulate intelligence.

An epigenetic predictor of death captures multi-modal measures of brain health

This paper introduces DNAm GrimAge, an epigenetic clock that predicts mortality and is associated with multiple brain health measures in older adults.

Childhood intelligence attenuates the association between biological ageing and health outcomes in later life

This study examines how DNAm PhenoAge, a biomarker of biological ageing, relates to health outcomes and cognitive ability across the lifespan, finding that early-life cognitive factors influence later-life health.

Identification of novel differentially methylated sites with potential as clinical predictors of impaired respiratory function and COPD

This study identifies 29 differentially methylated sites associated with respiratory function and COPD, showing improved prediction of COPD risk when added to clinical models.

Polygenic predictors of age-related decline in cognitive ability

This study uses polygenic scores to predict cognitive ability at age 70 and cognitive change from 70 to 79, finding limited predictive validity compared to APOE e4.

Improved prediction of chronological age from DNA methylation limits it as a biomarker of ageing

The paper improves age prediction from DNA methylation using larger datasets, showing reduced error and limitations in capturing biological ageing variation.

Brain Structural Differences Between 73- And 92-Year Olds Matched For Childhood Intelligence, Social Background, And Intracranial Volume

The paper matches 73- and 92-year-olds for childhood intelligence, social background, and brain size, finding significant structural brain differences linked to cognitive decline.