Pablo R. Murcia

Bovine H5N1 influenza viruses have adapted to more efficiently use receptors abundant in cattle

This study shows bovine H5N1 influenza viruses have adapted to efficiently use NeuGc receptors in cattle, enhancing replication without significantly altering zoonotic risk.

The canine respiratory epithelium is a permissive ecosystem for influenza interspecies transmission and emergence

This study shows that the canine respiratory tract supports influenza A virus replication and could facilitate interspecies transmission and emergence of new IAVs.

Understanding the emergence of the influenza A/H3N2 K subclade in its historical and evolutionary context

The paper investigates the emergence of the influenza A/H3N2 K subclade, finding limited antigenic change and age-dependent vaccine responses, suggesting non-antigenic selection pressures.

Infection of the bovine mammary gland by avian H5N1 subclade 2.3.4.4b influenza viruses

This study shows that avian H5N1 viruses can infect mammary tissue from three cattle breeds, highlighting the risk of viral transmission through milk and the need for cattle inclusion in H5N1 surveillance.

Polymerase mutations underlie early adaptation of H5N1 influenza virus to dairy cattle and other mammals.

Cattle B3.13 H5N1 polymerase gained PB2 M631L and PA K497R, boosting replication in bovine and human cells via better bovine ANP32A use; later PB2 E627K and D740N add activity.

The potential of H5N1 viruses to adapt to bovine cells varies throughout evolution

This study shows that H5N1 viruses' ability to adapt to bovine cells varies across genotypes and time, with key mutations in PB2 playing a role.

Spillover of H5 influenza viruses to vampire bats at the marine-terrestrial interface

This study identifies H5 influenza virus infections in vampire bats, showing their potential to spread the virus between marine and terrestrial ecosystems.

The cow udder is a potential coinfection site for influenza A viruses

The study shows cow mammary gland cells can support replication of multiple IAV strains and are susceptible to co-infection with human and avian IAVs, suggesting the udder may act as a site for viral reassortment.

Capturing variation in metagenomic assembly graphs with MetaCortex

MetaCortex improves metagenomic assembly by capturing intra-species diversity, achieving higher coverage and contiguity in simulated and mock communities.

DisCVR: Rapid viral diagnosis from high-throughput sequencing data

DisCVR rapidly detects human viruses in clinical samples using HTS data with high sensitivity and specificity, and is accessible on low-resource computers.