Huma Sethi

Neurodegeneration-inducing macromolecules exit the brain via nanovascular conduits formed by reticular fibroblasts

The paper identifies nanovascular conduits formed by reticular fibroblasts that remove toxic proteins like tau and Abeta from the brain in mice and humans.

Abnormal molecular signatures of inflammation, energy metabolism and vesicle biology in human Huntington disease peripheral tissues

The paper identifies molecular signatures of inflammation, energy metabolism, and vesicle biology in peripheral tissues of Huntington disease patients, suggesting their potential as biomarkers for clinical trials.

SARS-CoV-2 binding to ACE2 triggers pericyte-mediated angiotensin-evoked cerebral capillary constriction

This study shows SARS-CoV-2 binding to ACE2 on pericytes enhances angiotensin II-induced cerebral capillary constriction via AT1 receptors, suggesting AT1 blockers may mitigate brain blood flow reduction in infection.

Amyloid β oligomers constrict human capillaries in Alzheimer’s disease via signalling to pericytes

This study shows that amyloid β oligomers constrict human capillaries via pericyte signaling, reducing blood flow and contributing to Alzheimer’s disease pathology.