Author

Neha K. Prasad

University of California, San FranciscoORCID 0000-0003-4635-3795Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Microbiology· 1 Synthetic Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Assay:bulk RNA-seq· 1 Assay:CRISPR screen· 1 Research Focus:drug response / drug discovery· 1 Organism:E. coli· 1 Research Focus:gene regulatory network inference· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1

Frequent Co-Authors

Oren S. RosenbergiD· 2 shared Amy B. BantaiD· 1 shared Andrew H. NgiD· 1 shared Benjamin L. Oakes· 1 shared Benjamin Murray HeineikeiD· 1 shared Christina M. FitzsimmonsiD· 1 shared Christof FellmanniD· 1 shared David F. SavageiD· 1 shared

Activity by Year

2019-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 37 mutual co-author links

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2 shared papersMicrobiology

Oren S. RosenbergORCID

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2 papers

Recent·Most cited

Pseudomonas aeruginosa essential gene perturbations that confer vulnerability to the mammalian host environment

Neha K. Prasad, Ryan David Ward, Michelle A. Yu, Michael S. Kwon, Amy B. Banta, Oren S. Rosenberg, Jason M. Peters

This study identifies Pseudomonas aeruginosa genes whose partial knockdown increases vulnerability in a murine pneumonia model, highlighting potential targets for antibacterial strategies.

bioRxiv · Nov 5, 2024 · PreprintMicrobiology

Controlling CRISPR-Cas9 with ligand-activated and ligand-deactivated sgRNAs

Kale Kundert, James E. Lucas, Kyle E. Watters, Christof Fellmann, Andrew H. Ng, Benjamin Murray Heineike, Christina M. Fitzsimmons, Benjamin L. Oakes, Jiuxin Qu, Neha K. Prasad, Oren S. Rosenberg, David F. Savage, Hana El‐Samad, Jennifer A. Doudna, Tanja Kortemme

Inserting theophylline aptamers into the sgRNA yields ligand-activated and ligand-deactivated guides that tune CRISPRi in E. coli over 11x to 13x dynamic ranges, enabling two-ligand multiplexing.

Nature Communications · May 9, 2019Peer-reviewedSynthetic Biology✦ In-depth digest