Max E. Wilkinson

Minerva extracts RNA base-pairing, protein-contact and repeat maps from a genome language model without alignments, flagging unannotated structured loci and a phage ncRNA array reverse-transcribed into short cDNAs.

This study determines the structural basis of phage terminase recognition by Avs2 and Upx, revealing distinct binding mechanisms despite structural differences.

The paper characterizes DRT10, a reverse transcriptase defense system, showing it is regulated by host exonuclease SbcB and a phage-encoded SSB-like protein.

The paper shows that spliceosomes protect linear introns from degradation by assembling on them, and this process is conserved across stress and unstress conditions.

This study identifies Retron-Eco11 as a bacterial defense system that uses helicase proteins to trigger effector toxicity against phage infection.

Fine-tuned Evo 1 and Evo 2 genome language models designed complete ΦX174-like phage genomes; 16 of 285 assembled designs were viable, and some outperformed ΦX174 in competition.

This study investigates how the yeast splicing factor Fyv6 influences 3' splice site selection through transcriptomic, structural, and genetic analyses.

The paper presents a cryo-EM structure of the yeast P complex spliceosome post-exon ligation, revealing how the 3'-splice site is recognized through non-Watson-Crick pairing.