Cell BiologyPLoS PathogensPeer-reviewed
The adeno-associated virus Rep proteins target PP4:SMEK1 by preventing substrate-recruitment
Bram Vandewinkel, Sophie Torrekens, Zander Claes…·Els Henckaerts
This study identifies PP4:SMEK1 as a host restriction factor suppressed by AAV Rep proteins through substrate-recruitment interference, enhancing rAAV vector potency.
DOI 10.1371/journal.ppat.1014025