Anita A. Koshy

Copper transport is required for metabolism and persistence of Toxoplasma gondii

This study identifies two copper transporters in Toxoplasma gondii and shows their roles in parasite metabolism and persistence.

Defining neuronal responses to the neurotropic parasite Toxoplasma gondii

The paper compares neuronal transcriptional responses to Toxoplasma gondii and RNA viruses, identifying conserved and pathogen-specific immune responses in neurons.

The latent stage of Toxoplasma gondii is targeted by the immune response and host protective

This study shows immune pressure targets Toxoplasma gondii bradyzoites, which mitigate tissue damage and promote host-parasite survival.

Toxoplasma type II effector GRA15 has limited influence in vivo

This study investigates the role of Toxoplasma gondii type II effector GRA15 in vivo, finding it has a limited impact on brain parasite burden and immune cell numbers at 3 weeks post-infection.

Mapping host-microbe transcriptional interactions by dual perturb-seq

This paper introduces dual perturb-seq, a method combining CRISPR screening and single-cell RNA-sequencing to identify host-microbe transcriptional interactions, revealing new effector proteins in Toxoplasma gondii.

IFN-γ stimulated murine and human neurons mount anti-parasitic defenses against the intracellular parasite Toxoplasma gondii

This study shows that IFN-γ stimulated murine and human neurons can clear Toxoplasma gondii parasites, challenging the dogma that neurons cannot mount anti-parasitic defenses.

Transcriptional profiling reveals T cells cluster around neurons injected with Toxoplasma gondii proteins

The paper uses RNA-seq to compare transcriptional profiles of neurons infected with Toxoplasma gondii, bystander neurons, and controls, finding immune cell transcripts enriched in infected neurons.