Takashi Kondo

Preventing CpG island hypermethylation in oocytes safeguards mouse development

This study shows that KDM2A and KDM2B prevent aberrant DNA methylation in mouse oocytes, which is critical for early embryonic development.

CTCF looping is established during gastrulation in medaka embryos

The paper examines genome architecture changes during medaka gastrulation, finding that CTCF loops form while CTCF binding sites remain fixed, and transcription precedes mature domain formation.

KDM2 proteins constrain transcription from CpG island gene promoters independently of their histone demethylase activity

This study shows KDM2 proteins repress transcription from CpG island promoters without relying on their histone demethylase activity.

Adult Neurogenesis Conserves Hippocampal Learning Capacity

This study shows that adult neurogenesis in rats maintains hippocampal learning capacity by homeostatically renewing memory circuits, as evidenced by recovery after LTP saturation and modulation by neurogenesis manipulation.

FBXL19 recruits CDK-Mediator to CpG islands of developmental genes to prime them for activation during lineage commitment

The paper identifies FBXL19 as a CpG island-binding protein that recruits CDK-Mediator to developmental gene promoters in mouse ES cells, priming them for activation during lineage commitment.