Restoring mechanophenotype reverts malignant properties of ECM-enriched vocal fold cancer
Jasmin Kaivola, Karolina Punovuori, Megan R. Chastney, Hind Abdo, Gautier Follain, Mathilde Mathieu, Omkar Joshi, Yekaterina A. Miroshnikova, Fabian Krautgasser, Jasmin Di Franco, James R. W. Conway, Sofia Held, Fabien Bertillot, Jaana Hagström, Antti A. Mäkitie, , Johanna Ivaska
This study shows that restoring mechanophenotype or targeting YAP/TAZ can reverse malignant properties of vocal fold cancer by reducing nuclear YAP and β-catenin levels.
Nature Materials · Feb 20, 2026Peer-reviewedCell Biology