Hellyeh Hamidi

Signaling downstream of tumor-stroma interaction regulates mucinous colorectal adenocarcinoma apicobasal polarity

The paper identifies a signaling axis involving SorLA, integrin, and HER2/HER3 that regulates apicobasal polarity in mucinous colorectal adenocarcinoma and shows its therapeutic relevance.

Restoring mechanophenotype reverts malignant properties of ECM-enriched vocal fold cancer

This study shows that restoring mechanophenotype or targeting YAP/TAZ can reverse malignant properties of vocal fold cancer by reducing nuclear YAP and β-catenin levels.

Leupaxin inhibits the durotaxis and mechanosensitivity of metastatic breast cancer cells

This study shows that leupaxin inhibits durotaxis and mechanosensitivity in metastatic breast cancer cells by disrupting paxillin-FAK signaling.

EPLINα controls integrin recycling from Rab21 endosomes to drive breast cancer cell migration

The paper identifies EPLINα's role in integrin recycling via Rab21 endosomes, enhancing breast cancer cell migration and linking EPLIN isoform ratios to mesenchymal phenotypes.

ProLIF: a quantitative assay for investigating integrin cytoplasmic protein interactions and synergistic membrane effects on proteoliposomes

ProLIF quantitatively measures integrin-protein interactions in proteoliposomes using flow cytometry, enabling analysis of membrane effects on protein recruitment.