Megan R. Chastney

This study identifies two distinct mechanisms by which pancreatic cancer cells extravasate: protrusion-driven invasion and endothelial retraction, with implications for anti-metastatic strategies.

This study shows that TNS1 phase separation regulates adhesion dynamics by controlling the availability of inactive adhesion proteins through phosphorylation-dependent condensate formation.

This study shows SHANK3 regulates endothelial cell motility and tissue mechanics, affecting vascular development in zebrafish and mice.

This study shows that restoring mechanophenotype or targeting YAP/TAZ can reverse malignant properties of vocal fold cancer by reducing nuclear YAP and β-catenin levels.

The paper identifies EPLINα's role in integrin recycling via Rab21 endosomes, enhancing breast cancer cell migration and linking EPLIN isoform ratios to mesenchymal phenotypes.