Zachary J. Streblow

This study infects rhesus macaques with a recent ONNV clinical isolate, demonstrating viremia, immune activation, and clinical disease features similar to human infection.

This study identifies a first-in-class inhibitor of alphavirus nsP2 helicase activity, showing broad antiviral activity and in vivo efficacy against chikungunya virus.

This paper identifies and optimizes oxaspiropiperidine inhibitors targeting nsP2hel, showing nanomolar antiviral activity against multiple alphaviruses.

This study identifies and characterizes Rhesus CMV-encoded Fcγ-binding glycoproteins, showing they delay antibody-mediated immune control during primary infection.

This paper identifies and characterizes RA-0002034, a covalent inhibitor of CHIKV nsP2 protease, showing potent inhibition and selectivity against alphaviruses.