Cell BiologybioRxivPreprint
Mitochondrial proteostatic stress disrupts mitoribosome biogenesis and translation
Hauke Holthusen, Victoria A. Trinkaus, Carina Fernandez Gonzalez…·F. Ulrich Hartl
This study shows that proteostatic stress in mitochondria impairs mitoribosome biogenesis and translation, leading to respiratory deficiency and mitochondrial DNA loss.