The chromatin remodeling complex PRC2 safeguards cell fate in alveolar epithelial type 2 cells
Helen I. Warheit-Niemi, Jessie Huang, Kathleen C.S. Cook, Konstantinos–Dionysios Alysandratos, Sharlene Fernandes, Payel Basak, Barbara Zhao, Eitan Vilker, Carlos Villacorta-Martín, Amber Elitz, Pushpinder Bawa, Andrea Tóth, Michael J. Herriges, Darrell N. Kotton, William J. Zacharias
This study shows that PRC2 maintains AT2 cell fate in the adult lung by preventing transitions to ABI and basal-like states, both in vitro and in vivo.
bioRxiv · Mar 9, 2026 · PreprintGenetics