Ketone ester supplementation reduces age-associated B cell activation in aged mice without impairing antibody responses
Ariel Floro, Ritesh Tiwari, Mitsunori Nomura…·Eric M. Verdin
Author
Buck Institute for Research on AgingORCID 0009-0004-7460-8059Unclaimed ORCID profile · follow to get notified of new preprints
4 papers
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Ariel Floro, Ritesh Tiwari, Mitsunori Nomura…·Eric M. Verdin
Hiroyuki Matsui, Marlene Cervantes, Mir Mubashir Khalid…·Eric Verdin
The paper identifies age-associated Th2-like CD8 memory T cells in human blood and links their accumulation to health conditions like asthma and diabetes.
Daria Timonina, Genesis Vega Hormazabal, Indra Heckenbach…·Eric M. Verdin
This study shows that sleep disruption in mice increases cellular senescence in visceral adipose tissue, leading to oxidative stress and DNA damage, which may accelerate aging and age-related diseases.
Alan Tomusiak, Ariel Floro, Ritesh Tiwari…·Eric M. Verdin
The paper develops a novel epigenetic clock, IntrinClock, that measures age-related changes independent of immune cell composition, showing age reversal in reprogramming.