Author

Sergey Tumanov

The Heart Research InstituteORCID 0000-0002-0557-3153Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 2 Approach:experimental assay· 2 Organism:human· 2 Organism:mouse· 2 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:differential expression· 1 Research Focus:metabolism & bioenergetics· 1

Frequent Co-Authors

Alexander Ruvantha PintoiD· 1 shared Amit Chandra· 1 shared Christina A. BursilliD· 1 shared Christopher P. StanleyiD· 1 shared David A Robinson· 1 shared David Stephen CelermajeriD· 1 shared Elaina KellandiD· 1 shared Huamei He· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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1 shared paperPathology

Alexander Ruvantha PintoORCID

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2 papers

Recent·Most cited

2-Hydroxyglutarate Redirects Fatty Acid Partitioning to Mitigate Lipotoxic Stress and Preserve Metabolic Fuel

Niv Vigder, Amit Chandra, Nishith Shrimali, Sergey Tumanov, Vlad Elgart, Huamei He, Ryan M. Mulhern, Ram Prosad Chakrabarty, Navdeep S. Chandel, Stuart J. Cordwell, Steven P. Gygi, João A. Paulo, Joseph Loscalzo

This paper shows that 2-hydroxyglutarate (2HG) alters fatty acid partitioning, reducing lipotoxic stress by shifting fatty acids toward storage and away from oxidation and membrane synthesis.

bioRxiv · Aug 14, 2026 · PreprintCell Biology

Mitochondrial Dysfunction in Endothelial Cells Drives Greater Vascular Impairment in Females with Diabetes-Associated Peripheral Artery Disease

Siân Peta Cartland, Elaina Kelland, Natalie Le, Jaideep K. Singh, Madeleine Murphy, Rafaela Campos de Menezes, Jacqueline Ku, Lorna Beattie, Lisa Turner, Jacky Loa, Lauren M. Boccanfuso, Lauren Sandeman, Millie Jiang, Polina E. Nedoboy, Malathi S.I. Dona, , Mary Meltem Kavurma

This study identifies sex-specific mitochondrial dysfunction in endothelial cells of diabetic PAD patients, showing that MitoQ improves vascular function in females.

bioRxiv · Sep 22, 2025 · PreprintPathology