Changyang Zhou

A long-deletion mouse model of Williams syndrome reveals Ncf1-dependent modulation of vascular and neural phenotypes

This paper develops a long-deletion mouse model of Williams syndrome to study vascular and neural phenotypes, finding that Ncf1 modulates both cardiovascular and neuropsychological symptoms.

Prediction of meiosis-essential genes based upon the dynamic proteomes responsive to spermatogenesis

The paper predicts meiosis-essential genes by analyzing dynamic proteomes from spermatogenesis-synchronized mice and validates four candidates using knockout models.

CasRx-mediated RNA targeting prevents choroidal neovascularization in a mouse model of age-related macular degeneration

High-fidelity base editor with no detectable genome-wide off-target effects

The paper identifies base editor variants with reduced off-target effects on both DNA and RNA.