bioRxivMicrobiologyPreprint
Low dose inocula of SARS-CoV-2 B.1.1.7 variant initiate more robust infections in the upper respiratory tract of hamsters than earlier D614G variants
B. W.-Y. Mok, H. Liu, S.-Y. Lau, S. D. Deng, S. Liu, R. C.-Y. Tam, T. T.-L. Ng, J. S.-L. Leung, P. Wang, K. K.-W. To, J. F.-W. Chan, K.-H. Chan, K.-Y. Yuen, G. K.-H. Siu, H. Chen
Abstract
There is a lack of experimental evidence to explain how the B.1.1.7 variant spreads more quickly than pre-existing variants in humans. We found that B.1.1.7 displays increased competitive fitness over earlier D614G lineages in an in-vitro system. Furthermore,, we demonstrated that B.1.1.7 variant is able to replicate and shed more efficiently in the nasal cavity than other variants with lower dose and shorter duration of exposure.
Reproducibility ledger
Nobody has reported trying to reproduce this paper yet. Did you replicate an experiment or run the code? Your report saves the next lab a week.
Sign in to file a reproducibility report.
Related papers
- Enhanced fitness of SARS-CoV-2 variant of concern B.1.1.7, but not B.1.351, in animal models
L. Ulrich, N. J. Halwe, … C. Benarafa·bioRxiv·Jun 28, 2021
- SARS-CoV-2 B.1.1.7 infection of Syrian hamster does not cause more severe disease and is protected by naturally acquired immunity
I. A. Nunez, C. Z. Lien, … T. Wang·bioRxiv·Apr 2, 2021
- SARS CoV-2 variant B.1.617.1 is highly pathogenic in hamsters than B.1 variant
P. D. Yadav, S. Mohandas, … B. Bhargava·bioRxiv·May 5, 2021
- SARS-CoV-2 Delta variant pathogenesis and host response in Syrian hamsters
Sreelekshmy Mohandas, Pragya Dhruv Yadav, … Nivedita Gupta·VirusesPeer-reviewed·Sep 5, 2021
- The B.1.427/1.429 (epsilon) SARS-CoV-2 variants are more virulent than ancestral B.1 (614G) in Syrian hamsters
T. Carroll, D. Fox, … C. J. Miller·bioRxiv·Aug 25, 2021
- SARS-CoV-2 Delta variant induces severe damages in the nasal cavity from the first day post-infection in the Syrian hamster model.
Maxime Fusade-Boyer, Adèle Gambino, … Sophie Le Poder·VirulencePeer-reviewed·Jun 30, 2025