C. J. Miller

Administration of vaccine-boosted COVID-19 convalescent plasma to SARS-CoV-2 infected hamsters decreases virus replication in lungs and hastens resolution of the infection despite transiently enhancing disease and lung pathology.

This study shows that vaccine-boosted convalescent plasma reduces SARS-CoV-2 replication in hamsters but temporarily worsens disease and lung pathology.

Loss of genital epithelial barrier function is greater with depot-medroxyprogesterone acetate than intravaginal rings that release etonogestrel and ethinyl estradiol

This study compares the effects of DMPA and NuvaRing on genital epithelial barrier function in rhesus macaques, finding greater compromise with DMPA.

Spatial regulation of the glycocalyx component Podocalyxin is a switch for pro-metastatic function

This study identifies PODXL as a decoy receptor for GAL3, revealing its role in promoting metastasis through integrin-based invasion and differential cortical targeting regulated by ubiquitination.

Inducible Bronchus-Associated Lymphoid Tissue in SARS-CoV-2 Infected Rhesus Macaques

This study identifies inducible bronchus-associated lymphoid tissue in SARS-CoV-2 infected rhesus macaques, suggesting local immunity plays a role in infection.

The B.1.427/1.429 (epsilon) SARS-CoV-2 variants are more virulent than ancestral B.1 (614G) in Syrian hamsters

This study shows that the B.1.427/1.429 (epsilon) SARS-CoV-2 variants cause more severe disease and higher viral loads in the upper respiratory tract in Syrian hamsters compared to the ancestral B.1 (614G) strain.

Early embryonic loss following intravaginal Zika virus challenge in rhesus macaques

This study infects rhesus macaques intravaginally with Zika virus and finds that two of three pregnancies resulted in early embryonic loss with viral RNA detected at the maternal-fetal interface.

Comprehensive substrate specificity profiling of the human nek kinome reveals unexpected signaling outputs

The paper identifies phosphorylation-site motifs for the human Nek kinome, revealing dual-specificity in Nek10 and motif similarity between Nek6/7/9 and Plk1.