Author

J. F.-W. Chan

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 7 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 8 Research Focus:host-pathogen & immune response· 7 Organism:mouse· 4 Organism:human· 3 Assay:proteomics· 3 Research Focus:cell type annotation· 2 Research Focus:clustering· 1 Research Focus:trajectory inference· 1

Frequent Co-Authors

K.-Y. Yuen· 7 shared K. K.-W. To· 5 shared D. D. Ho· 4 shared H. Chen· 4 shared L. Liu· 4 shared P. Wang· 4 shared C. C.-S. Chan· 3 shared H. Chu· 3 shared

Activity by Year

2020-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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7 shared papersMicrobiology

K.-Y. Yuen

Mutual co-authors in cluster

Author profile →

8 papers

Recent·Most cited

Antibodies that neutralize all current SARS-CoV-2 variants of concern by conformational locking

L. Liu, R. G. Casner, Y. Guo, Q. Wang, S. Iketani, J. F.-W. Chan, J. Yu, B. Dadonaite, M. S. Nair, H. Mohri, E. R. Reddem, S. Yuan, V. K.-M. Poon, C. C.-S. Chan, K.-Y. Yuen, , D. D. Ho

This study identifies two antibodies that neutralize all SARS-CoV-2 variants by locking the spike protein in a down conformation, showing a novel mechanism and potential for prophylaxis.

bioRxiv · Apr 8, 2023 · PreprintMicrobiology

An elite broadly neutralizing antibody protects SARS-CoV-2 Omicron variant challenge

B. Zhou, R. Zhou, J. F.-W. Chan, M. Luo, Q. Peng, S. Yuan, B. W.-Y. Mok, B. Chen, P. Wang, V. K.-M. Poon, H. Chu, C. C.-S. Chan, J. O.-L. Tsang, C. C.-Y. Chan, K.-K. Au, , Z. Chen

This study identifies a broadly neutralizing antibody, ZCB11, effective against SARS-CoV-2 Omicron and Delta variants, showing protection in hamsters.

bioRxiv · Jan 5, 2022 · PreprintImmunology

Striking Antibody Evasion Manifested by the Omicron Variant of SARS-CoV-2

L. Liu, S. Iketani, Y. Guo, J. F.-W. Chan, M. Wang, L. Liu, Y. Luo, H. Chu, Y. Huang, M. S. Nair, J. Yu, K. K.-H. Chik, T. T.-T. Yuen, C. Yoon, K. K.-W. To, , D. D. Ho

This study shows that the Omicron variant of SARS-CoV-2 is highly resistant to neutralization by convalescent serum and vaccines, and many monoclonal antibodies.

bioRxiv · Dec 14, 2021Microbiology

SARS-CoV-2 hijacks neutralizing dimeric IgA for enhanced nasal infection and injury

B. Zhou, R. Zhou, J. F.-W. Chan, J. Zeng, Q. Zhang, S. Yuan, L. Liu, R. Robinot, S. Shan, J. Ge, H. Y.-H. Kwong, D. Zhou, H. Xu, C. C.-S. Chan, V. K.-M. Poon, , Z. Chen

This study shows that dimeric IgA antibodies can enhance SARS-CoV-2 nasal infection and injury in Syrian hamsters by engaging CD209 as an alternative receptor.

bioRxiv · Oct 5, 2021 · PreprintMicrobiology

Low dose inocula of SARS-CoV-2 B.1.1.7 variant initiate more robust infections in the upper respiratory tract of hamsters than earlier D614G variants

B. W.-Y. Mok, H. Liu, S.-Y. Lau, S. D. Deng, S. Liu, R. C.-Y. Tam, T. T.-L. Ng, J. S.-L. Leung, P. Wang, K. K.-W. To, J. F.-W. Chan, K.-H. Chan, K.-Y. Yuen, G. K.-H. Siu, H. Chen

This study shows that the B.1.1.7 SARS-CoV-2 variant replicates and sheds more efficiently in hamsters' nasal cavities than earlier D614G variants with lower doses and shorter exposure.

bioRxiv · Apr 19, 2021 · PreprintMicrobiology

SARS-CoV-2 spike D614G variant exhibits highly efficient replication and transmission in hamsters

B. W. Y. Mok, C. J. Cremin, S.-Y. Lau, S. Deng, P. Chen, A. J. Zhang, A. C.-Y. Lee, H. Liu, S. Liu, T. T.-L. Ng, H.-Y. Lao, E. L.-K. Lee, K. S.-S. Leung, P. Wang, K. K.-W. To, , H. Chen

This study compares SARS-CoV-2 strains in hamsters, finding that the D614G spike variant shows higher replication and transmission efficiency.

bioRxiv · Aug 28, 2020 · PreprintMicrobiology

NLRP3 inflammasome contributes to host defense against Talaromyces marneffei infection

H. Ma, J. F.-W. Chan, Y. P. Tan, L. Kui, C.-C. Tsang, S. L. Pei, Y.-L. Lau, P. C. Woo, P. P. Lee

This study shows that NLRP3 inflammasome activation is critical for host defense against Talaromyces marneffei infection by promoting IL-1β production and Th1/Th17 responses.

bioRxiv · Aug 17, 2020Microbiology

Potent Neutralizing Antibodies Directed to Multiple Epitopes on SARS-CoV-2 Spike

L. Liu, P. Wang, M. S. Nair, J. Yu, M. Rapp, Q. Wang, Y. Luo, J. F.-W. Chan, V. Sahi, A. Figueroa, X. V. Guo, G. Cerutti, J. Bimela, J. Gorman, T. Zhou, , D. D. Ho

The paper isolates and characterizes 61 SARS-CoV-2-neutralizing monoclonal antibodies from infected patients, identifying potent antibodies targeting multiple epitopes on the spike protein.

Nature · Jul 22, 2020Peer-reviewedMicrobiology