bioRxivMicrobiology
Persistent bacterial coinfection of a COVID-19 patient caused by a genetically adapted Pseudomonas aeruginosa chronic colonizer
J.-X. Qu, Z. Cai, Y. Liu, X. Duan, S. Han, Y. Zhu, Z. Jiang, Y. Zhang, C. Zhuo, Y. Liu, Y. Liu, L. Liu, L. Yang
Abstract
This study characterized a genetically adapted Pseudomonas aeruginosa small colony variant isolated from a COVID-19 patient who suffered persistent bacterial coinfection and eventually recovered from critical illness. Specification and modification of the isolates discovered at genomic and transcriptomic levels with aligned phenotypic observations indicated that these isolates formed excessive biofilm with elevated quorum sensing systems.
- organism: human
- assay: DNA methylation
- assay: whole-genome sequencing
- research focus: host-pathogen & immune response
- research focus: cell signaling & trafficking
- research focus: clustering
- approach: experimental assay
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