Circadian rhythm and melatonin

This study shows that light affects thalamo-cortical connectivity during a cognitive task, with differences based on time of day and age group.

This study shows HSP83 regulates Pdf transcription in clock neurons, affecting behavioral plasticity and circadian rhythms in Drosophila under stress.

This study shows melatonin reduces lipid accumulation and leptin resistance in 3T3-L1 cells by activating PI3K/AKT signaling through MT1/MT2 receptors.

This study shows that dim light at night increases seizure-like events and disrupts sleep in Cntnap2 knockout mice, with sex-specific effects.

This study identifies non-visual opsin expression in multiple tissues of the green anole lizard, highlighting tissue-specific patterns and evolutionary conservation.

This study shows that mitofusin 2 regulates mitochondrial and synaptic dynamics in SCN VIP neurons, affecting circadian rhythms and sleep in mice.

The paper investigates subunit shuffling dynamics in KaiC's central hub, revealing how ATPase activity regulates this process in the cyanobacterial circadian clock.

This study examines how different levels of melanopic illuminance affect cognitive performance and workload, finding non-linear relationships with both positive and negative effects at moderate and extreme light levels.

This study shows that cryptochrome loss in marine bristleworms increases lifespan and size, with hormonal pathways linked to sexual development and reproduction.

This study identifies a molecular pathway where melatonin promotes sleep by activating BK channels (Slo1) via MT1 receptors in SCN neurons, revealing a core circadian mechanism for sleep regulation.

This study conducts a GWAS of human pineal gland volume, identifying 34 genome-wide significant loci and highlighting genes and pathways related to sleep, metabolism, and neurodegeneration.

HairTime estimates chronotype from a single hair sample, showing it is influenced by age, sex, and work schedules, with lower circadian amplitude reducing prediction accuracy.

This study identifies SCN Neuromedin-S neurons as regulators of arousal, sleep-wake cycles, and body temperature rhythms through circuit analysis and single-nuclei RNA-Seq.

This study identifies phod1 as a gene regulating seasonal energy metabolism via the growth hormone pathway in Japanese medaka fish.

This study examines structural and functional changes in intrinsically photosensitive retinal ganglion cells (ipRGCs) in Alzheimer's disease, finding severe loss and altered function of these cells that may contribute to circadian rhythm disruption.

This study investigates the protective effects of BMAL1 overexpression in the suprachiasmatic nucleus on neurovascular deficits in diabetic mice, showing improvements in circadian rhythms, retinal function, and glucose homeostasis.

The paper identifies a conserved PER-DBT interaction critical for circadian timing and temperature compensation through structural and functional analyses in Drosophila and human cells.

This study shows that evening blue light exposure in adolescent mice increases avoidance behaviors and changes medial amygdala circuitry.

This study shows visible light affects behavioral memory and gene expression in C. elegans through a non-visual pathway involving cyp-14A5 and bZIP transcription factors.

The paper develops a method to infer circadian rhythm disruptions in tumors using phase differences between clock genes, finding cancer-type-specific alterations affecting patient survival.

This study uses VR head-mounted displays to deliver standardized light stimuli and finds melatonin suppression in 75% of participants.

The paper investigates how the waveform of regulatory functions affects period fluctuations in the circadian output system and finds that sinusoidal regulation minimizes these fluctuations.

This study identifies RITMO1 as a key circadian regulator in the diatom Phaeodactylum tricornutum, showing its impact on fluorescence, photosynthesis, and clock-controlled gene expression.

The paper shows that the dorsal vagal complex has circadian rhythms regulated by meal timing, with clock genes and their targets expressed rhythmically in vivo.

The paper develops MITE to infer functional connectivity in the SCN and finds a conserved, sparse connectome with hubs that drive circadian synchrony.

This paper introduces ROSLT, a Raspberry-Pi-based cyclometer for tracking mouse voluntary wheel running, showing it provides more accurate and consistent measurements than VDO M2.1 over time.

The paper investigates the role of clock genes period and timeless in regulating synaptogenesis and rhythmic changes in synaptic bouton numbers in Drosophila motor neurons.

This study identifies sex-specific roles of NPAS2 in fentanyl reward and addiction mechanisms in mice and humans.

CosinorTest is an R Shiny app for circadian and differential analysis of transcriptomic data using Cosinor models, offering tools for rhythmicity detection, differential pattern assessment, and visualization.

This study shows that genetic variation in the period gene affects daily and seasonal timing in Ostrinia nubilalis, with reduced per mRNA abundance linked to later activity and shorter diapause.