Lauren M. DePoy

Prenatal circadian rhythm disruption induces sex-specific substance use and mood-related phenotypes in mice

This study shows that prenatal circadian rhythm disruption in mice leads to sex-specific behavioral changes in adulthood, with females showing mood-related issues and males showing substance use-like behaviors.

Molecular and cellular rhythms in excitatory and inhibitory neurons in the mouse prefrontal cortex

This study identifies cell-type and sex-specific gene expression and electrophysiological rhythms in mouse prefrontal cortex neurons, showing differences in rhythmic transcripts and biological processes between excitatory pyramidal cells and inhibitory PV interneurons.

Sex-specific Regulation of Fentanyl Reward by the Circadian Transcription Factor NPAS2

This study identifies sex-specific roles of NPAS2 in fentanyl reward and addiction mechanisms in mice and humans.

Circadian rhythms in the gut microbiota shape sex differences in host gene expression and metabolism

This study shows that microbial circadian rhythms influence sex differences in host gene expression and metabolism, with diet affecting these sex-specific patterns.

The Suprachiasmatic Nucleus Regulates Anxiety-Like Behavior in Mice

This study shows that manipulating SCN neural activity in mice affects anxiety-like behavior but not depressive-like behavior, with dampened activity rhythms correlating with increased anxiety.

Circadian- and sex-dependent increases in intravenous cocaine self-administration in Npas2 mutant mice

This study investigates how NPAS2 mutations affect cocaine self-administration in mice, showing sex- and time-of-day-dependent changes in reward and motivation.