Gastrointestinal motility and disorders

This study investigates the role of Cntnap2 in GI motility using Cntnap2 mutant mice, finding altered colonic motility without affecting ENS organization.

This study compares three wholemount dissection methods for neuronal subtype markers in the mouse myenteric plexus, finding that one method reduces marker labeling.

The paper shows that PIEZO2 in dorsal root ganglia neurons regulates gut motility by sensing mechanical stretch, affecting gastrointestinal transit.

This study investigates how central Alzheimer's pathology affects gastrointestinal mucus function in a rat model, finding altered secretion, composition, and barrier properties.

This study investigates neural responses to gastrointestinal sensations using a vibrating capsule, showing improved perceptual accuracy and correlated neural activity.

The paper identifies and characterizes Prox2+ and Runx3+ vagal sensory neurons and shows their essential roles in esophageal peristalsis and swallowing.

This study shows that perinatal high fat diet exposure reduces oxytocin inputs and increases corticotropin releasing factor inputs to vagal neurocircuits, leading to altered gastric motility and stress responses.

This study compares transcriptomic profiles of porcine and human colonic enteric nervous system to identify conserved regional programs and their response to vagal nerve stimulation.

This study investigates stomach-brain coherence in rats using fMRI and gastric slow wave recordings, finding that vagus nerve activity mediates this coherence, which varies between fasting and fed states.

The paper demonstrates that the enteric nervous system is organized into circumferential stripes with regionally distinct development and neuronal composition.

This study uses high-resolution ultrasound and speckle tracking to visualize and quantify fetal gastrointestinal motility in chick embryos, showing synchronized contractions develop late in fetal life.

The paper develops a computational model of gastric motility to show how second messenger exchange between interstitial cells of Cajal ensures robust entrained slow-wave propagation during peristalsis.

This study shows androgens regulate colonic motility in mice and humans, with lower testosterone levels linked to IBS symptom severity.

The paper investigates how gastric electrical stimulation (GES) orientation affects neural responses in the nucleus tractus solitarius (NTS) in rats, finding orientation-specific activation of gastric neurons.

This study shows that intestinal bacteria maintain adult enteric neurons via TLR2-induced neurogenesis in mice, with implications for treating colonic motility disorders.

The paper shows microbiota induce AhR in enteric neurons, enabling them to respond to environmental signals.

This study uses machine learning to predict emesis and gastrointestinal states in ferrets using implanted myoelectric signals.

The paper introduces an image analysis technique using image velocimetry and spectral analysis to quantify gut contraction strength, frequency, and wave speed in larval zebrafish.