Gastrointestinal motility and disorders

Modeling Inflammation-Driven Colon Hypertrophy and Motility Changes in Gulf War Illness

The paper develops a computational model to simulate inflammation-driven colon hypertrophy and motility changes in Gulf War Illness using PB-exposed mouse data.

Microbial metabolism of mannitol as a tracer for the non-invasive measurement of oral-cecal transit

This paper introduces a non-invasive method to measure oral-cecal transit time in mice by tracking microbial oxidation of 13C-mannitol to 13CO2 using spectroscopy and calorimetry.

Impact of Enteric Neuronal Loss on Intestinal Cell Composition

This study investigates how loss of the enteric nervous system in zebrafish affects intestinal cell composition and identifies similar changes in human HSCR tissues.

D- and L-Lactate enhance intestinal barrier function via activation of an apical HCAR1/Giα pathway in a human colonic epithelial cell model

DYNAMIC CHANGES TO THE INTESTINAL ENVIRONMENT OCCUR THROUGHOUT RECOVERY FROM EXPERIMENTAL ISCHAEMIC STROKE

This study profiles the gastrointestinal tract over three months post-stroke in an experimental model, showing structural and microbial changes that persist chronically.

Macrophage Immune-Competent Colon Assembloids for Functional Interrogation of Neuroinflammation-Induced Colonic Dysmotility

This study introduces an immune-competent colon assembloid model to investigate how neuroinflammation affects colonic motility, finding impaired neuronal regeneration and smooth muscle remodeling as key mechanisms.

Development of a Novel Benzodiazepine to Delineate Peripheral GABA-A Signaling Mechanisms in Visceral Pain Syndromes

This study develops a novel benzodiazepine, Li633, that targets peripheral GABAA receptors to reduce visceral pain in IBS and FD models.

Monocytes Mobilized by Gut Neurons Remodel the Enteric Nervous System

The paper identifies that post-inflammatory GI dysmotility results from ENS remodeling driven by monocyte recruitment and neuroinflammation, which can be prevented by enhancing HIF1 signaling in enteric neurons.

A Cellular Basis for Heightened Gut Sensitivity in Females

The paper identifies an estrogen-responsive paracrine pathway in the gut that increases sensitivity in females by enhancing communication between enteroendocrine cells and sensory nerves.

Optogenetics-integrated gut organ culture system connects enteric neurons dynamics and gut homeostasis

The paper develops an optogenetics-integrated gut organ culture system to study enteric neuron dynamics and their impact on gut homeostasis, revealing distinct neuronal roles in immune and barrier functions.

Obesity induces phenotypic switching of gastric smooth muscle cells through the activation of the PPARD/PDK4/ANGPTL4 pathway

This study identifies the PPARD/PDK4/ANGPTL4 pathway as a mechanism by which obesity induces phenotypic switching of gastric smooth muscle cells, leading to dysmotility.

Luminal nutrients activate distinct patterns in submucosal and myenteric neurons in the mouse small intestine

The paper shows that different luminal nutrients activate distinct calcium responses in submucosal and myenteric neurons of the mouse small intestine.

A Compartmental Model for Simulating the Gut-Brain Axis in Gastric Function Regulation

This paper introduces a compartmental model of the gut-brain axis to simulate gastric function regulation, showing inhibitory and excitatory effects of sympathetic and parasympathetic pathways on digestion.

Gpr37 modulates the severity of inflammation-induced GI dysmotility by regulating enteric reactive gliosis.

This study identifies Gpr37 as a gene expressed in enteric glia cells of the myenteric plexus and shows its role in LPS-induced reactive gliosis and GI dysmotility.

Enteric glia regulate Paneth cell secretion and intestinal microbial ecology

This study shows that enteric glia regulate Paneth cell secretion and microbial ecology but have minimal effects on overall intestinal epithelial transcription.

Synaptic cell adhesion molecule Cdh6 identifies a class of sensory neurons with novel functions in colonic motility

The paper identifies Cdh6 as a marker for a novel class of sensory neurons in the mouse colon that regulate colonic motility through specific electrophysiological properties and functional responses.

Enteroendocrine Cells Regulate Intestinal Barrier Permeability

This study shows enteroendocrine cells are essential for maintaining intestinal barrier integrity and that their secreted hormones PYY and octreotide can restore barrier function in inflammatory conditions.

Self-organized patterning of peristaltic waves by suppressive actions in a developing gut

The paper investigates how peristaltic wave origins in chicken embryos transition from random to organized positions through suppressive actions and lateral inhibition.

Attention in Irritable Bowel Syndrome: A Systematic Review of Affected Domains and Brain-Gut Axis Interactions

This systematic review examines attentional deficits and brain-gut axis interactions in IBS patients, identifying attentional biases and altered brain activation patterns.

Enteric glutamatergic interneurons regulate intestinal motility

This study identifies glutamatergic neurons as key regulators of intestinal motility by showing their synaptic connections and functional roles in gut transit.

Mechanisms of Activation and Serotonin release from Human Enterochromaffin Cells

This study investigates mechanisms of serotonin release from human enterochromaffin cells using organoids and functional assays, identifying key receptors and signaling pathways involved.

Magnetic Resonance Imaging of Gastric Motility in Conscious Rats

This paper demonstrates GI MRI in conscious rats, showing faster gastric emptying and stronger peristalsis compared to anesthetized rats.

T cells regulate intestinal motility and shape enteric neuronal responses to intestinal microbiota.

This study shows T cells regulate intestinal motility and enteric neuronal responses to microbiota, with distinct roles in ileum and colon.

Segmental regulation of intestinal motility by colitis and the adaptive immune system in the ileum and colon

This study investigates how colitis and the adaptive immune system regulate intestinal motility in the ileum and colon using a mouse model.

Characterizing enteric neurons in Dopamine Transporter (DAT)-Cre reporter micereveals dopaminergic subtypes with dual-transmitter content

This study characterizes dopaminergic neurons in the gut using a DAT-cre reporter mouse line, revealing distinct subtypes with dual-transmitter content.

Peripheral serotonergic neurons regulate gut motility and anxiety-like behavior

This study shows that peripheral serotonergic neurons affect gut motility and anxiety-like behavior, suggesting potential therapeutic targets.

Morphological, molecular, and functional characterization of mouse glutamatergic myenteric neurons

The paper characterizes VGLUT2-positive enteric neurons in mice, revealing their unique morphology, gene expression, and functional activation via colorectal stretch.

Loss of ASD-Related Molecule Cntnap2 Affects Colonic Motility in Mice

This study investigates the role of Cntnap2 in GI motility using Cntnap2 mutant mice, finding altered colonic motility without affecting ENS organization.

Comparison of wholemount dissection methods for neuronal subtype marker expression in the mouse myenteric plexus

This study compares three wholemount dissection methods for neuronal subtype markers in the mouse myenteric plexus, finding that one method reduces marker labeling.

PIEZO2 in somatosensory neurons controls gastrointestinal transit

The paper shows that PIEZO2 in dorsal root ganglia neurons regulates gut motility by sensing mechanical stretch, affecting gastrointestinal transit.