Gastrointestinal motility and disorders

The hypothalamic paraventricular nucleus mediates vagus nerve stimulation-enhanced gastric emptying

This study shows that the hypothalamic paraventricular nucleus mediates vagus nerve stimulation-enhanced gastric emptying and anti-inflammatory effects through motilin receptor expression and cytokine regulation.

Regional macrophage specialization shapes intestinal neuroimmune function

This study shows that intestinal macrophages have region-specific trophic requirements and neuroimmune functions, with CSF1 playing a key role in small-intestinal nitrergic neuron-macrophage interactions.

Reciprocal control of the stomach and intestine by viscerosensory neurons in caudal brainstem

The paper shows that NPFF neurons in the caudal brainstem control gastric emptying and intestinal transit by responding to duodenal nutrient sensing.

Neurogenic colonic motility patterns and gut transit disrupted in a mouse model of Rett Syndrome

This study identifies disrupted neuronal muscarinic signaling in the enteric nervous system of a Rett syndrome mouse model, leading to gut motility and transit defects.

Maladaptive Piezo1 Mechanotransduction Drives Smooth Muscle Aging in the Gut

This study identifies maladaptive Piezo1 mechanotransduction as a driver of smooth muscle aging in the gut, showing it impairs contractility and contributes to gastrointestinal dysfunction.

Daily Bowel Movements are Associated with Stronger Gut-Brain Phase-Amplitude Coupling and Better Cognitive Performance

In 76 healthy middle-aged women, daily bowel movements went with better composite cognitive scores, stronger gastric-phase to EEG-alpha coupling and higher faecal short-chain fatty acids than less-frequent ones.

Mapping Enteric Neural Circuits by Anterograde Transsynaptic Tracing

The paper introduces mWmC, a viral tracer for mapping enteric neuronal circuits, showing it selectively labels postsynaptic neurons without affecting other cell types.

Gastric-brain coupling dynamics in response to a cognitive challenge reveal distinct autonomic and psychological correlates in healthy individuals and patients with irritable bowel syndrome

This study examines gastric-brain coupling during cognitive tasks in healthy individuals and IBS patients, finding preserved dynamics in IBS but altered autonomic and psychological associations.

The Critical Role of Pdyn-Lineage Enteric Neurons in Colonic Motility and Visceral Interoception

This study identifies Pdyn-lineage neurons as sensory enteric neurons in the mouse colon that regulate motility and visceral interoception through optogenetic activation.

Oleuropein stimulates peripheral serotonin secretion via voltage-dependent Ca2+ channels and acutely regulates central function

This study shows oleuropein stimulates 5-HT secretion from enterochromaffin cells via voltage-dependent Ca2+ channels and affects depression-like behavior in mice.

Bidirectional communication between neurons in the mesentery and ileal myenteric neurons

This study characterizes mesenteric neurons in adult mice, showing they connect with the enteric nervous system and provide inhibitory feedback to the myenteric plexus during intestinal distension.

C1qa⁺ muscularis macrophages maintain enteric synaptic homeostasis to regulate gastrointestinal motility

This study identifies C1qa⁺ muscularis macrophages as regulators of enteric synaptic homeostasis and gastrointestinal motility through complement-dependent mechanisms.

A multiverse analysis of stomach-brain coupling in humans

This study uses multiverse analysis to evaluate the consistency of gastric-brain coupling measurements across different analytic pipelines in EEG-EGG data from healthy humans.

A Biophysical Model of Human Colonic Motor Pattern Generation in Health and Disease

This paper develops a biophysical model of human colonic motor patterns that reproduces healthy and disease states, showing how parameters affect motility.

Reduced enteric Bdnf expression and TrkB-dependent regulation of Vip in a Mecp2-null mouse model of Rett syndrome-associated gastrointestinal dysmotility

This study identifies reduced enteric Bdnf and altered VIPergic signaling as key mechanisms of GI dysmotility in a Mecp2-null mouse model of Rett syndrome.

The Colonic Mucus Layer is Thinner and is Associated with Goblet Cell Hyperplasia in the db/db Mouse Model of Type 2 Diabetes

This study examines the impact of diabetes on the colonic mucus layer and goblet cells in db/db mice, finding a thinner mucus layer and goblet cell hyperplasia.

Enteric sensory neurons for nutrient detection and gut motility

This study creates a single-cell atlas of the murine enteric nervous system, identifies molecularly defined IPANs, and shows their role in nutrient detection and gut motility regulation.

A vagal gut-brain axis for feeding induced gastric secretion

The paper identifies cell-type-specific vagal and enteric circuits that control meal-induced gastric secretion and shows segregation of secretory and motor functions.

EXPRESSION OF ANO1 IN HUMAN GASTROINTESTINAL TRACT DURING EMBRYONIC AND FETAL DEVELOPMENT

The paper examines the spatial and temporal expression of ANO1 in human gastrointestinal tract during embryonic and fetal development as a marker for interstitial cells of Cajal and smooth muscle cells.

A novel enteric pacemaker activity in Drosophila

The paper identifies a novel pacemaker activity in Drosophila midgut called superstalsis, linked to specific muscle activation and gene expression under physiological conditions.

Glutamine alters the response to stress in mice with diet-induced obesity in a sex-dependent manner.

This study investigates how glutamine affects stress responses in obese mice, showing sex-dependent differences in glucose tolerance, corticosterone levels, and gut microbiota.

Impact of Slow Wave Abnormalities and Impaired Coordination of Pyloric Closure and Antral Contraction on Gastric Emptying: A Compartmental Modeling Study

This paper develops a computationally efficient gastric compartmental model to simulate diseased stomach function, showing that slow wave abnormalities and impaired coordination delay gastric emptying and reduce mixing efficiency.

The Gut-Brain Axis Shapes Cognitive-Emotional Processing: Evidence for Attentional Avoidance of Bloating Cues in IBS

This study finds IBS patients selectively avoid bloating-related stimuli, with anxiety modulating this bias but not causing it, highlighting gut-brain interactions in cognitive-emotional processing.

A case for slow-wave morphology as a functional biomarker of gastric disease

This study investigates gastric slow-wave morphology as a biomarker for disease, finding differences between healthy controls and patients with chronic unexplained nausea and vomiting.

Purinergic signalling and calcium dynamics: potential drivers in the onset of coordinated intestinal motility in human fetal development

The paper investigates the emergence of coordinated intestinal motility in human fetal development, identifying calcium dynamics and purinergic signaling as key drivers.

Prucalopride ameliorates delayed gastrointestinal transit and social behaviour in a mouse model of 15q duplication syndrome

This study shows prucalopride improves GI transit and social behavior in a mouse model of Dup15q syndrome by targeting 5-HT4 receptors.

Experimental data supporting a novel hypothesis for the rhythmic initiation of proximal colon motor complexes

The paper uses in situ calcium imaging to identify activity patterns in ICC-SM and ENS myenteric neurons that predict the timing of proximal colon motor complexes, proposing a novel hypothesis for their rhythmic initiation.

Optimization of protocols for immunohistochemical assessment of enteric nervous system in formalin fixed human tissue.

This paper optimizes immunohistochemical protocols for assessing the enteric nervous system in formalin-fixed human tissue using multiple protein markers.

Reduced enteric BDNF-TrkB signaling drives stress-dependent glucocorticoid-mediated GI dysmotility

This study shows stress-induced glucocorticoid signaling reduces BDNF-TrkB signaling in the enteric nervous system, leading to GI dysmotility, and identifies TrkB as a potential therapeutic target.

Sympathetic Nervous System Overactivation Induces Colonic Eosinophil-Associated Microinflammation and Contributes to the Pathogenesis of Irritable Bowel Syndrome

This study shows that sympathetic nervous system overactivation in a maternal separation model leads to colonic eosinophil infiltration and visceral hypersensitivity, contributing to IBS pathogenesis.