Ovarian function and disorders

The Identification of Key Genes and Biological Pathways in Polycystic Ovary Syndrome and its Complications by Next Generation Squancing (NGS) and Bioinformatics Analysis

This study identifies key genes and pathways in PCOS and its complications using NGS data and bioinformatics analysis.

Dynamic changes in the transcriptome of oocytes during adolescent-onset PCOS in mice

This study analyzes transcriptome changes in oocytes of adolescent-onset PCOS mice, identifying key pathways and genes involved in disease progression.

Genetic Associations with Polycystic Ovary Syndrome: The Role of The Mitochondrial Genome; A Systematic Review and Meta-analysis

This study reviews and meta-analyzes genetic associations between the mitochondrial genome and polycystic ovary syndrome, finding specific mtDNA variants and copy number differences.

Effects of electroacupuncture on the expression of hypothalamic neuropeptide Y and ghrelin in pubertal rats with polycystic ovary syndrome

This study investigates the effects of electroacupuncture on hypothalamic neuropeptide Y and ghrelin in pubertal rats with PCOS, finding that electroacupuncture improves symptoms by modulating these factors.

Loci on chromosome 12q13.2 encompassing ERBB3, PA2G4 and RAB5B are associated with polycystic ovary syndrome

The paper identifies 15 SNPs associated with androgen production in theca cells and a haplotype on chromosome 12q13.2 linked to PCOS and AMH levels.

The role of obesity in female reproductive conditions: A Mendelian Randomisation Study

This study uses Mendelian randomisation to investigate the causal effects of obesity on female reproductive conditions, finding that central obesity and metabolic hormones mediate these associations.

Genome-wide association study meta-analysis identifies three novel loci for circulating anti-Müllerian hormone levels in women

Leveraging Northern European population history; novel low frequency variants for polycystic ovary syndrome

This study identifies three novel low-frequency variants associated with PCOS using a Finnish-Estonian GWAS, highlighting the value of population-specific genetic analysis.

Polycystic ovary syndrome susceptibility loci inform disease etiological heterogeneity

This study identifies genetic clusters associated with PCOS subtypes and finds causal links between BMI, SHBG, and PCOS.

Hepatocyte androgen receptor in females mediates androgen-induced hepatocellular glucose mishandling and systemic insulin resistance

This study shows that deleting the hepatic androgen receptor in female mice prevents androgen-induced insulin resistance and glucose intolerance.

Phenotypic clustering reveals distinct subtypes of polycystic ovary syndrome with novel genetic associations

This study identifies two stable subtypes of PCOS with distinct genetic associations through phenotypic clustering and GWAS.

Association between methylenetetrahydrofolate reductase gene C677T polymorphism and susceptibility to polycystic ovary syndrome

This study performs a meta-analysis of 24 case-control studies to assess the association between MTHFR C677T polymorphism and PCOS susceptibility, finding significant links in Asian populations but not in Caucasians.

A genome-wide association study of polycystic ovary syndrome identified from electronic health records

This paper identifies novel genetic variants associated with PCOS using EHR-based GWAS and validates them in independent cohorts.

Colocalization highlights genes in hypothalamic-pituitary-gonadal axis as potentially mediating polycystic ovary syndrome risk

This study uses Bayesian colocalization to identify genes potentially mediating polycystic ovary syndrome risk by linking genetic risk loci to intermediate phenotypes.

A polygenic and phenotypic risk prediction for Polycystic Ovary Syndrome evaluated by Phenome-wide association studies

This study develops a polygenic and phenotypic risk score for PCOS using EHR data, showing improved detection and identifying shared metabolic and endocrine comorbidities.

Family-based quantitative trait meta-analysis implicates rare noncoding variants in DENND1A in pathogenesis of polycystic ovary syndrome

This study identifies rare noncoding variants in DENND1A associated with PCOS traits through family-based whole-genome sequencing and quantitative trait meta-analysis.

Identification of target candidate in Polycystic ovarian syndrome and in vitro evaluation of therapeutic activity of the designed RNA Aptamer

The paper identifies S100A8 as a drug target in PCOS and validates an RNA aptamer that inhibits its activity in vitro.

Genome-wide association study of anti-Mullerian hormone levels in pre-menopausal women of late reproductive age and relationship with genetic determinants of reproductive lifespan

This study identifies a genetic variant associated with AMH levels in pre-menopausal women and links AMH to reproductive lifespan.

Large-Scale Genome-Wide Meta Analysis of Polycystic Ovary Syndrome Suggests Shared Genetic Architecture for Different Diagnosis Criteria.

This study performs a large-scale genome-wide meta-analysis of PCOS cases and identifies genetic loci associated with PCOS and related traits, showing shared genetic architecture across different diagnostic criteria.

Polycystic Ovary Syndrome As An Endogenous Alcoholic Polycystic Ovary Syndrome

This study investigates the link between polycystic ovary syndrome (PCOS) and endogenous alcohol production, finding that PCOS may be an endogenous alcoholic syndrome due to gut microbiota producing ethanol and acetaldehyde.