Ovarian function and disorders

Hypoadiponectinemia does not enhance anxiety-like behaviour in a lean PCOS-like mouse model

This study examines the relationship between adiponectin levels and anxiety-like behavior in PCOS and finds that reduced adiponectin does not exacerbate anxiety in a PCOS-like mouse model.

AMH regulates ovary size by counteracting ovarian follicle cluster effects.

The paper shows AMH limits ovarian follicle overgrowth by counteracting the survival-promoting effect of proximity to large follicles.

A genome-wide association study of anti-Müllerian hormone (AMH) levels in Samoan women

This paper identifies eleven genome-wide suggestive loci and seven transcriptome-wide significant genes associated with AMH levels in Samoan women using GWAS and TWAS.

Brain-specific Gata4 downregulation in Greywick female mice models the metabolic subtype of polycystic ovary syndrome

This study shows that Gata4 downregulation in the hypothalamus of Greywick female mice models the metabolic subtype of PCOS by affecting fertility and food intake genes.

Altered Hormone and Bioactive Lipid Plasma Profile in Rodent Models of Polycystic Ovarian Syndrome Revealed by Targeted Mass Spectrometry

This study identifies altered plasma lipid profiles in rodent PCOS models using targeted mass spectrometry, revealing both similarities and differences compared to human PCOS.

Sex Modifies the Effect of Genetic Risk Scores for Polycystic Ovary Syndrome on Metabolic Phenotypes

This study examines how sex influences the genetic risk of PCOS on metabolic traits using polygenic risk scores and EHR data.

Genetic Associations with Polycystic Ovary Syndrome: The Role of The Mitochondrial Genome; A Systematic Review and Meta-analysis

This study reviews and meta-analyzes genetic associations between the mitochondrial genome and polycystic ovary syndrome, finding specific mtDNA variants and copy number differences.

Effects of electroacupuncture on the expression of hypothalamic neuropeptide Y and ghrelin in pubertal rats with polycystic ovary syndrome

This study investigates the effects of electroacupuncture on hypothalamic neuropeptide Y and ghrelin in pubertal rats with PCOS, finding that electroacupuncture improves symptoms by modulating these factors.

The role of obesity in female reproductive conditions: A Mendelian Randomisation Study

This study uses Mendelian randomisation to investigate the causal effects of obesity on female reproductive conditions, finding that central obesity and metabolic hormones mediate these associations.

Genome-wide association study meta-analysis identifies three novel loci for circulating anti-Müllerian hormone levels in women

Leveraging Northern European population history; novel low frequency variants for polycystic ovary syndrome

This study identifies three novel low-frequency variants associated with PCOS using a Finnish-Estonian GWAS, highlighting the value of population-specific genetic analysis.

Polycystic ovary syndrome susceptibility loci inform disease etiological heterogeneity

This study identifies genetic clusters associated with PCOS subtypes and finds causal links between BMI, SHBG, and PCOS.

Phenotypic clustering reveals distinct subtypes of polycystic ovary syndrome with novel genetic associations

This study identifies two stable subtypes of PCOS with distinct genetic associations through phenotypic clustering and GWAS.

A genome-wide association study of polycystic ovary syndrome identified from electronic health records

This paper identifies novel genetic variants associated with PCOS using EHR-based GWAS and validates them in independent cohorts.

A polygenic and phenotypic risk prediction for Polycystic Ovary Syndrome evaluated by Phenome-wide association studies

This study develops a polygenic and phenotypic risk score for PCOS using EHR data, showing improved detection and identifying shared metabolic and endocrine comorbidities.

Family-based quantitative trait meta-analysis implicates rare noncoding variants in DENND1A in pathogenesis of polycystic ovary syndrome

This study identifies rare noncoding variants in DENND1A associated with PCOS traits through family-based whole-genome sequencing and quantitative trait meta-analysis.

Genome-wide association study of anti-Mullerian hormone levels in pre-menopausal women of late reproductive age and relationship with genetic determinants of reproductive lifespan

This study identifies a genetic variant associated with AMH levels in pre-menopausal women and links AMH to reproductive lifespan.

Large-Scale Genome-Wide Meta Analysis of Polycystic Ovary Syndrome Suggests Shared Genetic Architecture for Different Diagnosis Criteria.

This study performs a large-scale genome-wide meta-analysis of PCOS cases and identifies genetic loci associated with PCOS and related traits, showing shared genetic architecture across different diagnostic criteria.