Ovarian function and disorders

DIRECTION-AWARE INTEGRATED BIOINFORMATICS ANALYSIS REVEALS CONCORDANT AND DISCORDANT MOLECULAR SIGNATURES LINKING TYPE 2 DIABETES MELLITUS AND POLYCYSTIC OVARY SYNDROME

This study identifies concordant and discordant molecular signatures between PCOS and T2DM using direction-aware analysis of transcriptomic data from GEO datasets.

Hypoadiponectinemia does not enhance anxiety-like behaviour in a lean PCOS-like mouse model

This study examines the relationship between adiponectin levels and anxiety-like behavior in PCOS and finds that reduced adiponectin does not exacerbate anxiety in a PCOS-like mouse model.

Defective Hippocampus-Dependent Spatial Memory in Mouse Model of Polyendocrine metabolic ovarian syndrome (PMOS, formerly PCOS).

This study shows that a DHEA-induced PMOS mouse model exhibits anxiety-like behavior and impaired spatial memory, with altered hippocampal gene expression.

miR-6818-5p Drives Ovarian Granulosa Cell Dysfunction in PCOS via Targeting HSD17B2 and Modulating PI3K/Caspase-9 Axis

Integrative Multi-cohort Transcriptomics and Network Pharmacology Analysis Reveals Key Network Nodes and Potential Drug Clues in PCOS Granulosa Cells

The paper identifies key genes and potential drugs for PCOS by integrating transcriptomics and network pharmacology across multiple cohorts.

Integrative Identification and Characterization of PCOS-Associated lncRNAs From the Interface of Genetic Association, Transcriptomics, and Gene Structure Evolution

The paper identifies and characterizes PCOS-associated lncRNAs by integrating genetic association, transcriptomics, and evolutionary analysis.

Inhibition of the androgen-activating enzyme AKR1C3 selectively decreases systemic and intra-adipose 11-oxygenated androgens in women

Inhibition of AKR1C3 reduces 11-oxygenated androgens but not classic androgens in women.

Cell type-resolved transcriptomic map of skeletal muscle in women with polycystic ovary syndrome

This study creates a single-nuclei transcriptomic atlas of skeletal muscle in women with PCOS, identifying cell-type-specific dysregulation and therapeutic targets.

Altered metabolic health during pregnancy in mice with lean polycystic ovary syndrome-like traits from high prenatal AMH

This study examines metabolic changes in PCOS-like mice during pregnancy, finding altered glucose homeostasis but no major metabolic dysfunction despite high-fat diet exposure.

Serum Bile Acid Dysregulation in Polycystic Ovary Syndrome: Quantitative Insights from Mass Spectrometry-Based Profiling

This study identifies bile acid dysregulation in PCOS using mass spectrometry, showing altered levels and ratios of specific bile acids linked to metabolic and hormonal parameters.

Metabolomic Profiling of Serum Biomarkers in Women with Polycystic Ovary Syndrome: Insights from an Untargeted Approach

This study identifies metabolic alterations in PCOS using untargeted metabolomics, linking them to insulin resistance and inflammation.

AMH regulates ovary size by counteracting ovarian follicle cluster effects.

The paper shows AMH limits ovarian follicle overgrowth by counteracting the survival-promoting effect of proximity to large follicles.

A Systems-Level Transcriptomic Analysis of Polycystic Ovary Syndrome as a Mitochondrial-Immunometabolic Disorder

This study identifies mitochondrial and immune dysregulation in PCOS through transcriptomic analysis of endometrial tissue, revealing novel gene associations and regulatory mechanisms.

Possible Synergistic Modulation of Hormonal Balance and Ovarian Structure by Clomiphene Letrozole Co-Administration in a Rodent Model of Hyperandrogenism

This study evaluates the effects of clomiphene-letrozole co-administration on hormonal, inflammatory, and ovarian parameters in a rat model of hyperandrogenism, finding improved endocrine and antioxidant profiles with combination therapy.

Toll-like Receptor 4 Contributes to PCOS-like Metabolic and Reproductive Pathogenesis

This study shows that TLR4 deficiency reduces PCOS-like symptoms in a mouse model by improving metabolic and reproductive health and reducing inflammation.

Pathogenic variation in insulin resistance genes is common in polycystic ovary syndrome (PCOS): a strategy for causal gene discovery using whole-exome sequencing (WES) in complex traits

This study identifies pathogenic variants in insulin resistance genes in PCOS patients using whole-exome sequencing, highlighting IR as a central pathway in PCOS.

Nutritional Triggers of PCOS and NAFLD: A Comparative Analysis of Diets in Female C57BL/6J Mice

This study compares the effects of two obesogenic diets on metabolic and reproductive health in female mice, finding diet composition influences specific outcomes in obesity-related disorders.

A genome-wide association study of anti-Müllerian hormone (AMH) levels in Samoan women

This paper identifies eleven genome-wide suggestive loci and seven transcriptome-wide significant genes associated with AMH levels in Samoan women using GWAS and TWAS.

Brain-specific Gata4 downregulation in Greywick female mice models the metabolic subtype of polycystic ovary syndrome

This study shows that Gata4 downregulation in the hypothalamus of Greywick female mice models the metabolic subtype of PCOS by affecting fertility and food intake genes.

Altered Hormone and Bioactive Lipid Plasma Profile in Rodent Models of Polycystic Ovarian Syndrome Revealed by Targeted Mass Spectrometry

This study identifies altered plasma lipid profiles in rodent PCOS models using targeted mass spectrometry, revealing both similarities and differences compared to human PCOS.

Systems Genetics Cytokine Screen Identifies T cells as Necessary for Letrozole-Induced LH Elevation in a PMOS-like Mouse Model

The paper identifies T cells and TNF-β as associated with PMOS-like phenotypes and shows T cells are necessary for letrozole-induced LH elevation in a mouse model.

Construction of a ceRNA network specific for granulosa cells in PCOS

The paper constructs a ceRNA network specific to granulosa cells in PCOS using RNA-seq data from PCOS and control samples, identifying differentially expressed miRNAs, lncRNAs, and mRNAs.

A Mendelian randomization study identifies the causal association between plasma mitochondrial CHCHD proteins and polycystic ovary syndrome

This study uses Mendelian randomization to show that plasma mitochondrial CHCHD2 increases PCOS risk while CHCHD10 reduces it, suggesting potential therapeutic targets.

Gene regulatory activity associated with PCOS revealed DENND1A-dependent testosterone production

The paper identifies gene regulatory mechanisms in PCOS-associated loci, showing DENND1A-dependent testosterone elevation through experimental and genetic analyses.

Genomic and proteomic evidence for hormonal and metabolic foundations of polycystic ovary syndrome

This study identifies 31 plasma proteins and expands genetic loci associated with PCOS, highlighting metabolic and hormonal influences and polygenic risk effects on cardio-metabolic outcomes.

Understanding and Predicting Polycystic Ovary Syndrome through Shared Genetics with Testosterone, SHBG, and Chronic Inflammation

This study identifies genetic loci associated with PCOS and shows genetic correlations with inflammation and sex hormones, improving PCOS prediction through polygenic risk scores.

Circulating anti-Müllerian hormone levels in pre-menopausal women: novel genetic insights from a GWAS meta-analysis

This paper identifies six genetic loci associated with circulating anti-Müllerian hormone levels in pre-menopausal women through a GWAS meta-analysis, including novel signals and biological pathway insights.

Induced-hyperandrogenism in female rats: assessing possible modulation of neurobehavioural and neurotransmitter changes following clomiphene/letrozole intervention

This study investigates the effects of clomiphene and letrozole on neurobehavioural and neurochemical changes in female rats with induced hyperandrogenism.

Sex Modifies the Effect of Genetic Risk Scores for Polycystic Ovary Syndrome on Metabolic Phenotypes

This study examines how sex influences the genetic risk of PCOS on metabolic traits using polygenic risk scores and EHR data.

Transcriptome-wide association study identified candidate genes associated with polycystic ovary syndrome

This study identifies 422 and 177 candidate genes associated with PCOS in whole blood and ovary through transcriptome-wide association analysis and functional enrichment.