Memory and Neural Mechanisms

The paper investigates how auditory aversive conditioning affects alpha-band brain activity, finding threat-specific reductions and no generalization to similar tones.

This study investigates how lateral hypothalamic GABAergic neurons encode and express alcohol-related memories through behavioral experiments and optogenetic manipulation.

This paper compares cytoarchitectonic delineations of medial temporal lobe subregions by four neuroanatomists, finding higher agreement in some areas and less in others.

This study shows that head direction representations in mouse retrosplenial cortex and anterodorsal thalamus are coordinated during visual cue rotation and maintained in darkness.

This study shows that a history of avoidance does not impair extinction learning in male rats, regardless of whether avoidance is possible during extinction.

This study shows that optogenetic reactivation of fear memories in the hippocampus reproduces cellular activity patterns seen during natural memory recall, highlighting neuronal-astrocytic coupling in fear behavior.

This study shows that basal forebrain cholinergic activation modulates amygdala neuron activity based on reward contingency, affecting conditioned behavior but not unconditioned responses.

The paper investigates whether the successor representation supports hierarchical abstraction for goal-directed behavior by analyzing human choices in a virtual museum task.

The paper shows that a consistent spatial map in the medial entorhinal cortex is necessary for successful spatial memory in mice.

The paper identifies basal forebrain cholinergic neurons as essential partners in threat memory engrams, showing distinct activation patterns for learned and innate threats.

This study investigates how parahippocampal neurons encode task-relevant information during goal-directed navigation in dynamic environments, finding that neural activity mismatches correlate with task performance.

This study shows that an obesogenic diet during adolescence impairs specific memory types via overactivation of hippocampal pathways, and targeting these pathways can reverse deficits.

Hippocampome.org v2.0 provides data-driven computational simulations of rodent hippocampal circuits using expanded neuron type classifications and empirical data.

This study shows that biphasic Npas4 expression suppresses fear memory consolidation and promotes behavioral flexibility in mice by facilitating fear extinction.

The paper shows that the entorhinal cortex represents an abstract value space during decision making with a grid-like pattern aligned to the most informative value axis.

This paper develops an unsupervised method to classify dentate spikes into types 1 and 2 based on waveform features, showing high accuracy and revealing differences in DS characteristics between apoE3 and apoE4 mice.

This study identifies that Vb neurons in the medial entorhinal cortex project to the hippocampal dentate gyrus in mice, with a preference for the ventral DG.

The paper uses simulations to show how synaptic competition among stable grid cell inputs leads to dynamic spatial reorganization of place fields over time in larger environments.

This study shows that fear conditioning in humans leads to distinct movement patterns, and training active defensive movements reduces fear responses long-term.

The paper shows that artificial place fields in CA1 pyramidal cells of mice produce synthetic theta phase precession, indicating local generation within CA1.

This study shows that prefrontal cortex projections to insular cortex modulate functional connectivity and coding ability to support short-term memory in mice.

This study shows acetylcholine and netrin-1 work together to enable persistent firing in the entorhinal cortex, essential for spatial working memory.

This study investigates how object identity and reward outcomes are encoded in the corticohippocampal hierarchy, finding distinct roles for secondary visual cortex and perirhinal cortex.

The paper uses optogenetic silencing to disrupt hippocampal inputs to the retrosplenial cortex and shows it impairs spatial working memory retrieval, with effects lasting beyond light exposure.

This study shows that inhibition matures to promote hippocampal ripple emergence starting from postnatal day 10 in mice.

The paper identifies LEC subpopulations in mice that represent experiential epochs around reward during navigation, showing their role in encoding reward-related information.

This paper presents a biophysically plausible model of hippocampal networks that co-evolve latent representations with behavioral task structure, showing task-specific development of necessary representations.

This study investigates how cholinergic modulation affects rearing behavior in rats during a spatial memory task, finding that inhibiting cholinergic neurons increases rearing duration.

This study shows that the Pavlovian fear system enables flexible and efficient exploratory decision-making by balancing safety and efficiency through uncertainty-based avoidance.

The paper models hippocampal CA3 as a Hopfield-like network that stores and retrieves correlated and decorrelated encodings, showing how inhibitory tone controls transitions between concept and example representations, and extends this to multitask learning in neural networks.