Electrospun Nanofibers in Biomedical Applications

Carrier-Limited Release Risk in Electrospun Nanofibers for Regenerative Endodontics: Constraint Discovery from 25 Formulations

The paper evaluates 25 electrospun PVP fiber formulations for regenerative endodontics, using machine learning to identify constraints and release risks, finding carrier-limited release and recommending further testing.

Functional Performance of Electrospun Tissue-Engineered Heart Valve Scaffolds Across Geometries Under Aortic Conditions

FiberPro 1.0: Multiagent AI-Guided Design for High-Throughput Production and Conformal Deposition of Functional Protein Micro/Nanofibers

FiberPro 1.0 uses a multiagent AI framework to design and optimize functional protein micro/nanofiber production through high-throughput spinning and real-time feedback, achieving spinnable formulations in two iterations.

The hydrocup: a hollow electrospun scaffold for in vivo hydrogel-laden cell delivery

The paper develops a hollow electrospun scaffold (hydrocup) for in vivo cell delivery, showing it retains cells and releases cytokines for 6 weeks in rats.

Designing Well-Organized Touch-Spun 3D Scaffolds: The Role of Interfiber Spacing in Cell Proliferation

The paper evaluates touch-spun 3D scaffolds with varying interfiber spacing to determine optimal conditions for NIH/3T3-GFP fibroblast growth, finding that 50.61 m spacing maximizes cell viability.

Architecture-Dependent Transition from Quasi-2D to 3D Cell-Scaffold Interactions in Ultrafine Electroprinted Cellulose Scaffolds

This study investigates how scaffold architecture influences cell-scaffold interactions, showing that scaffold dimensionality and fiber spacing control the transition from quasi-2D to 3D cellular behavior.

Medicament identity rather than total loading governs the morphology of electrospun poly(vinylpyrrolidone) nanofibers for regenerative endodontics: a machine learning analysis of a failure-inclusive dataset

The paper uses machine learning to analyze a dataset of electrospun nanofibers, finding that medicament identity, not total loading, better predicts fiber morphology in regenerative endodontics.

Antibiofilm peptide incorporated PHBV-PLLA nanofibrous mat for wound infection treatment and healing

This study develops a bioactive nanofibrous mat incorporating an antibiofilm peptide to enhance wound healing and infection treatment.

Characterizing in vivo degradation of electrospun biodegradable nanofibers by size-exclusion chromatography

This study quantifies the in vivo degradation of biodegradable nanofibers using size-exclusion chromatography, revealing material- and environment-dependent degradation patterns.

Heparinized Elastomeric Nanofibrillar Grafts: A Novel Approach for Mechanically Tunable, Cell-Supportive, and Thromboresistant Vascular Substitutes

This paper introduces heparin-functionalized elastomeric nanofibrillar grafts that meet three key requirements for vascular grafts: mechanical tuning, cell support, and thromboresistance, showing promising in vitro and pilot in vivo results.

3D Microscale Mechanical Simulations of Hydrogel Coated Electrospun Meshes

This paper uses 3D microscale mechanical simulations to predict bulk mechanical properties of hydrogel-coated electrospun meshes, revealing non-affine deformations and stress-strain differences.

Wave-inspired MEW scaffolds for enhanced ligament tissue regeneration

This study develops wave-inspired MEW scaffolds that mimic ligament structure and mechanics, supporting cell adhesion, proliferation, and matrix synthesis.

A Bioelectronic Scaffold for Label-Free, Real-Time Monitoring of Wound Healing

This paper introduces a bioelectronic scaffold that enables label-free, real-time monitoring of wound healing through electrical impedance spectroscopy.

Melt Electrowritten Microfiber-Hydrogel Composite Scaffolds for Aligned Muscle Tissue Engineering

This paper develops a composite microfiber-hydrogel scaffold using melt-electrowriting to enhance muscle tissue engineering by improving mechanical strength, alignment, and myoblast differentiation.

3-Dimensional Piezoelectric Fibrous Constructs for Muscle Regeneration

This study develops piezoelectric PHBV scaffolds for muscle regeneration, showing enhanced electromechanical properties and cytocompatibility.

Electrospinning of hydroxypropyl chitosan nanofibers for bone regeneration application

The paper evaluates the osteogenic effect of hydroxypropyl chitosan-poly(vinyl alcohol) nanofiber mats on MC3T3 cells using staining and gene expression analysis.

A hybrid bioprinting-electrospinning platform integrating nanofibers and mesenchymal cell spheroids for customizable wound healing dressings

This paper introduces a hybrid bioprinting-electrospinning platform for customizable wound healing dressings using nanofibers and mesenchymal cell spheroids, showing improved cell viability and wound closure.

Electrospun Fiber Surface Roughness Modulates Human Monocyte-Derived Macrophage Phenotype

This study shows that surface roughness of electrospun fibers modulates macrophage phenotype by altering cytokine release and CD206/CD80 expression in vitro and in vivo.

Nanofibrous Wound Dressing with a Smart Drug Delivery System: Poly(N-Isopropylacrylamide)-Conjugated Polycaprolactone Nanofibers Loaded with Curcumin

This paper develops a smart wound dressing using PCL nanofibers conjugated with PNIPAAm and loaded with curcumin, showing controlled drug release and enhanced wound healing.

Investigation and optimization the effect of electrical stimulation parameters on the differentiation of human adipose mesenchymal stem cells into neurons-like cells on carbon nanofibers

This study optimizes electrical stimulation parameters to induce neuronal differentiation of human adipose mesenchymal stem cells on carbon nanofibers, finding that 1500 uA, 500Hz square waveform improves neural gene expression.