Olfactory and Sensory Function Studies

This study investigates how vasopressin modulates excitability in different neuron subtypes of the rat olfactory bulb, revealing subtype-specific effects on synaptic responses and calcium influx.

The paper investigates how fast-spiking interneurons in the olfactory bulb provide high-fidelity inhibition through synaptic detonation mechanisms.

This study shows that TMEM16B, a Ca2+-activated Cl- channel, influences the response kinetics and action potential generation of olfactory sensory neurons, while the CNG channel primarily determines response delay and adaptation.

The paper develops an olfactory stimulation fMRI system in marmosets to study olfactory pathway activity and its potential link to neurodegenerative diseases.

This study characterizes the synaptic connectivity and electrophysiological properties of the nucleus of the lateral olfactory tract (NLOT) in mice, revealing its role in integrating olfactory and amygdalar inputs to assign emotional value to odors.

This study shows that learning enhances odour discrimination in the piriform cortex by integrating non-olfactory contextual information into neuronal responses.

The paper identifies a topographic organization in the posterolateral cortical amygdala (plCoA) that controls innate olfactory attraction and aversion through distinct cell types and projections.

This study examines neuropathological changes in the olfactory bulb and tract of COVID-19 patients, finding no significant inflammation but age-related decline in anti-CD68 reactivity and mild increases in phospho-Syn and phospho-tau signals in affected brains.

The paper investigates how feedforward and feedback inputs to the olfactory bulb encode odor information, finding that feedback provides sparse, decorrelated representations of complex odors.

The paper identifies p63/Keratin5-positive basal cells in the vomeronasal organ's sensory and non-sensory epithelia, showing their role in self-renewal and differentiation into apical cells.

The paper shows that in the olfactory cortex, mechanosensory feedback decouples odor concentration representation from inhalation speed, ensuring sniff-invariant odor encoding.

The paper identifies two distinct subpopulations of VP cholinergic neurons that encode valence of olfactory stimuli and differentially regulate approach and avoidance behaviors.

This study shows mice can discriminate odor plume intermittency and the olfactory bulb encodes this property, with sniffing behavior influencing both performance and neural representation.

This study shows that metabolic state affects odor processing in the human olfactory bulb, with higher gamma power observed during hunger compared to satiety.

This study generates single-cell transcriptomic atlases of the mouse vomeronasal organ, revealing new cell types, lineage relationships, and molecular mechanisms of receptor specification.

This study investigates how inflammation in the olfactory epithelium affects the olfactory bulb in schizophrenia and related disorders, finding correlations between immune-related gene expression and OB volume reduction.

This study shows that lifelong olfactory enrichment in mice improves cognitive performance and brain connectivity, linked to noradrenergic plasticity and network remodeling in aging.

This study identifies Foxj1's role in regulating olfactory cilia formation and OSN differentiation in zebrafish and mice.

The paper performs single-cell transcriptomics on mouse vomeronasal sensory epithelium to identify cell types and functional differences, finding distinct ER environments in neuronal subtypes.

This study uses fMRI to investigate whether nostril-specific odor stimulation produces asymmetrical activation in olfactory cortical structures in humans.

This study confirms the presence of a functional vomeronasal system in fossorial water voles through histological and immunohistochemical analysis.

This study shows that short-term consumption of ultra-processed semi-synthetic diets impairs olfactory function and brain metabolism in mice.

The paper shows that odor information from each nostril is encoded separately in the piriform cortex, with ipsilateral odors processed faster than contralateral ones.

The paper replicates and extends findings showing that lifelong olfactory deprivation leads to orbitofrontal cortex morphological changes, but not in piriform cortex.

This study shows that olfactory function can be preserved in mice with severe olfactory bulb degeneration due to altered circuitry compensating for lost structures.

The paper investigates molecular diversity and connectivity patterns in accessory olfactory system neurons, revealing lineage- and sex-specific differences in connectivity.

The paper demonstrates that the olfactory bulb encodes ortho and retronasal odor modality through mitral cell activity and shows that synaptic inhibition affects this encoding.

This study shows that olfactory bulb activity synchronizes limbic circuits in the beta frequency range during neonatal development, shaping communication in the lateral entorhinal cortex, hippocampus, and prefrontal cortex.

This study records electrophysiological properties of human olfactory sensory neurons using acute slices, revealing functional transduction mechanisms involving cAMP.