Janardhan Prasad Bhattarai

TRPML1 positions lysosomes and regulates actin-membrane linkers in astrocyte processes

This study investigates how TRPML1 regulates lysosome positioning and actin-membrane linkers in astrocyte processes, influencing synaptic contacts.

A novel iPSC model of Bryant-Li-Bhoj neurodevelopmental/neurodegenerative syndrome demonstrates the role of histone H3.3 in chromatin dynamics, neuronal differentiation, and maturation

This paper uses an iPSC model of BLBS to show that the H3.3 L48R variant disrupts chromatin dynamics, neuronal differentiation, and electrophysiological function.

Brain-wide neuronal circuit connectome of human glioblastoma

This study shows human glioblastoma cells integrate into brain-wide neuronal circuits, exhibit diverse connectivity, and respond to neuromodulatory inputs like acetylcholine, which promotes invasion and survival.

Circuit mechanism underlying fragmented sleep and memory deficits in 16p11.2 deletion mouse model of autism

This study identifies heightened LC-NE neuron activity and altered connectivity as causes of sleep fragmentation and memory deficits in a 16p11.2 deletion ASD mouse model.

Bidirectional modulation of negative emotional states by parallel genetically-distinct basolateral amygdala pathways to ventral striatum subregions

The paper identifies two genetically distinct BLA pathways to the ventral striatum that bidirectionally modulate negative emotional states through projection-specific mechanisms.

Inflammation-related pathology in the olfactory epithelium: its impact on the olfactory system in psychotic disorders

This study investigates how inflammation in the olfactory epithelium affects the olfactory bulb in schizophrenia and related disorders, finding correlations between immune-related gene expression and OB volume reduction.

Self-grooming promotes social attraction in mice via chemosensory communication

The paper shows that self-grooming in mice increases social attraction through chemosensory cues, using optogenetic induction of grooming behavior.

Aversive Learning Increases Release Probability of Olfactory Sensory Neurons

This study shows that aversive learning increases the release probability of olfactory sensory neurons in mice, correlating with freezing behavior during fear retrieval.

A cortical pathway modulates sensory input into the olfactory striatum

This study investigates the functional role of the cortico-striatal pathway from the piriform cortex to the olfactory tubercle in mice, showing it modulates odor coding through monosynaptic connections.