Olfactory and Sensory Function Studies

Odor representations are structured by heterogeneous tuning and concentration-dependence of functionally distinct olfactory sensory neuron subpopulations.

The paper examines how odorant representations in the olfactory bulb are structured by concentration-dependent tuning of functionally distinct OSN subpopulations across different concentration regimes.

Molecularly defined olfactory bulb output neurons exhibit selective yet overlapping projections

The paper identifies molecularly defined subtypes of olfactory bulb output neurons and their distinct projection patterns to cortical targets.

`Silent' mitral cells emerge from common feature subtraction

The paper explains 'silent' mitral cells in the olfactory bulb using a computational model that incorporates common feature subtraction, showing baseline activity cancels common olfactory features to enhance odor response.

Olfactory Deficits and Structural Anomalies of the Peripheral Olfactory System in 22q11.2 Deletion Syndrome

This study investigates olfactory deficits and structural anomalies in the olfactory system among individuals with 22q11.2 deletion syndrome compared to psychosis spectrum and typically developing controls.

Aging reshapes odor-evoked dynamics in central olfactory circuits

This study examines how aging affects odor-evoked neural dynamics in the olfactory bulb and piriform cortex of mice, revealing changes in excitation, inhibition, and oscillatory patterns.

Multiomic evidence for microbial contributions to species-specific olfactory communication in wild tamarins

The paper investigates microbial contributions to species-specific olfactory communication in wild tamarins by analyzing scent gland microbiomes and volatile organic compounds.

Odor-evoked activity outside canonical areas of olfactory information transmission is visualized by ODORTRAP and modulated by diet-induced obesity

The paper uses ODORTRAP to visualize odor-evoked activity outside canonical olfactory areas and shows diet-induced obesity modulates this activity in hypothalamic regions.

Functional Profiling of a Human Odorant Receptor Using Olfactory Cilia Links its Activation to Odor Quality

This study uses a transgenic approach to increase OR expression in OSNs and links OR10G4 activation to specific odor qualities through ligand screening.

The chemistry of families: Linking body odor composition to olfactory perception

This study links body odor composition to olfactory perception in human families, finding that relatedness and sex predict both perceptual and chemical similarity.

Imaging mitral/tufted glomeruli in the mouse olfactory bulb using the genetically encoded voltage indicator ArcLight

The paper uses ArcLight to image voltage dynamics in mitral/tufted glomeruli of anesthetized mice, revealing odor-evoked excitatory and suppressive signals and concentration-specific responses.

Fine ultrastructural organization of glomerular neuropil in the developing zebrafish olfactory bulb

The paper reveals the fine ultrastructural organization of protoglomeruli in the developing zebrafish olfactory bulb, showing their subdivision into microglomeruli with distinct mitral cell arrangements.

Localized SARS-CoV-2 Infection Triggers a Tissue-Wide Antiviral Response and Functional Impairment of Olfactory Sensory Neurons

This study investigates how SARS-CoV-2 infection affects olfactory sensory neurons in mice, showing localized infection triggers a tissue-wide antiviral response and functional impairment without neuronal loss.

TEX15 safeguards neuronal diversity in the mouse olfactory system

This study identifies Tex15 as a gene required for maintaining diversity in odorant receptor expression in mouse olfactory neurons.

Genetic and behavioural repertoires support olfactory communication in wild capuchin monkeys

This study examines VR gene repertoires and olfactory behaviors in wild capuchin monkeys, finding evolutionary constraint on VRs and a diverse set of olfactory behaviors suggesting a role in social communication.

Recurrent interactions between olfactory bulb and olfactory cortex support cross-sniff perceptual continuity in humans

The paper shows that recurrent interactions between the olfactory bulb and piriform cortex in humans maintain perceptual continuity by integrating sensory information across successive sniffs.

Gene duplication shaped the origin and evolution of the vertebrate olfactory combinatorial code

The paper examines how gene duplication shaped the evolution of the vertebrate olfactory combinatorial code by analyzing receptor-ligand interactions and ancestral sequences.

Chemosensory ERP Suggest Peripherally Driven Olfactory-Trigeminal Interactions in Healthy Older Adults

This study investigates olfactory-trigeminal interactions in older adults using ERP and behavioral tasks, finding that ipsilateral co-stimulation enhances trigeminal localization and ERP amplitudes, suggesting peripheral mechanisms dominate.

An inductive bias for generalization in mouse olfactory learning

This study investigates generalization versus memorization in mice using an olfactory categorization task, finding that mice prefer generalization over memorization.

The vomeronasal system decodes biological state from patterns of bile acid chemosignals

This study shows that the vomeronasal system decodes biological state from bile acid patterns, revealing sensitivity to rare ligands and information encoding through stimulus whitening.

Activation of Neurotensin Receptor 1 in entorhinal cortex rescues olfactory generalization in two mouse models of autism

This study shows that activating neurotensin receptor 1 in the entorhinal cortex rescues olfactory generalization deficits in two ASD mouse models.

Insulin controls olfactory gain at the first central synapse by regulating periglomerular neuron excitability

The paper shows insulin reduces olfactory sensitivity by inhibiting periglomerular neurons in mice, altering sensory input before it reaches mitral cells.

Expansion of Olfactory Receptor Family 14 Across Fossorial and Insectivorous Mammals

The paper identifies OR14 gene family expansion in fossorial and insectivorous mammals, linking it to ecological adaptation and convergent evolution.

Deep anatomical and ultrastructural classification of neurons in the zebrafish olfactory bulb

The paper classifies neuron types and their connectivity in the zebrafish olfactory bulb using ultrastructural features from electron microscopy.

Effects of acute intranasal allergen exposure on resident immune cells and sensory neurons in the mouse olfactory epithelium

This study examines how acute intranasal allergen exposure affects immune cells and sensory neurons in the mouse olfactory epithelium, finding minimal immune cell changes but increased OSN chemosensory sensitivity.

Odors Smell Like Their Components: A Linear Framework for Predicting Olfactory Mixture Perception

The paper shows that odor mixtures can be predicted linearly from component odorant profiles, challenging the assumption of nonlinear interactions.

Rapid odorant metabolism organizes identity- and timing-based odor representations by olfactory bulb inputs and outputs

The paper shows that rapid odorant metabolism in the olfactory mucosa generates secondary odorants that reshape odor representations by introducing timing-based distinctions between inhaled and internally-generated odorants.

Computationally mapping olfactory receptors to odor percepts using docking energy scores

The paper maps olfactory receptors to odor percepts using docking energy scores, showing a direct relationship between receptors and specific smells.

Evidence that Dogs Can Use Temporal Difference in Odorant Arrival to Discriminate Odorant Mixtures

This study shows dogs can detect very short differences in odorant arrival times, distinguishing between synchronous and asynchronous odorant mixtures under natural sampling conditions.

Distributed representations of chemosensory valence in a naive vertebrate brain

The paper maps chemosensory valence-related neuronal activity in larval zebrafish, showing distributed brain-wide organization rather than localized regions.

Odor preference maps to cohesive transcriptional domains in the olfactory bulb

The paper identifies transcriptional domains in the zebrafish olfactory bulb that correlate with odor preference and shows specific neuronal subtypes are recruited based on odor preference.