Helminth infection and control

This study identifies tissue-specific gene co-expression networks and core genes in Parascaris univalens following ivermectin exposure, revealing differential transcriptional responses and potential resistance mechanisms.

The paper investigates the role of MyD88 in ovine resistance to Haemonchus contortus infection using molecular and computational methods.

This study clones and sequences IL-6 and IL10 genes in sheep, analyzes their structural domains, and reports their potential antiparasitic role against Haemonchus contortus.

This study investigates praziquantel's effects on C. elegans development and identifies potential genetic factors, including cct-8, that influence susceptibility.

The paper introduces a microfluidics-based nematode sensory assay to study gustation and shows that ivermectin inhibits gustatory ability in parasitic nematodes.

This study shows Fasciola hepatica juveniles use host plasminogen-binding proteins to activate plasmin, aiding their migration through the intestinal wall.

This paper identifies widespread benzimidazole resistance in Ancylostoma caninum from dogs across the USA, including a novel β-tubulin mutation and confirms its functional significance.

The paper investigates the role of C. elegans β-tubulin genes in albendazole resistance, finding that tbb-2 modifies sensitivity and ben-1 mutations primarily confer resistance.

This study compares transcriptomic profiles of in vitro and in vivo maintained Fasciola hepatica juveniles to identify gene expression differences that may explain growth and development variations.

The paper maps resistance loci for three anthelmintic classes in a parasitic nematode, identifies novel alleles for benzimidazoles and levamisole, and implicates cky-1 in ivermectin resistance.

This paper identifies gene expression changes associated with ivermectin resistance in parasitic nematodes through genetic crosses and RNA-seq, revealing upregulation of specific genes linked to neuronal plasticity and chloride homeostasis.

The paper examines gene expression and microbiome changes in goats infected with Haemonchus contortus and treated with different interventions, identifying treatment-specific genes and microbial composition shifts.

The paper characterizes Fasciola gigantica in Punjab, Pakistan, identifying genetic differences and potential dispersal routes among neighboring countries in the Indian subcontinent.

The paper confirms the presence of Dicrocoelium dendriticum in the Himalaya ranges of Pakistan using genetic analysis of flukes collected from the Chitral valley.

This study analyzes the global genetic diversity of Haemonchus contortus, revealing human-driven dispersal and climate adaptation mechanisms.

The paper develops a high-throughput method to determine anthelmintic resistance allele frequencies in gastrointestinal nematodes using Illumina Mi-seq sequencing.

This study identifies gut microbiota differences between susceptible and resistant horses infected with strongyles, linking microbial composition to immune responses and infection outcomes.

The paper compares the transcriptome of Haemonchus contortus parasites from vaccinated and control sheep to assess vaccine-induced gene expression changes.