Helminth infection and control

A new semi-automated, motility-based screening assay for discovery of compounds with activity against the juvenile stage of Fasciola hepatica

This paper introduces a semi-automated motility-based assay to screen compounds against Fasciola hepatica juveniles, identifying three new compounds with nanomolar activity.

Evolutionary and epidemiological considerations for anthelmintic treatments in ruminant livestock

This study develops a simulation framework to evaluate anthelmintic resistance management strategies in ruminants by integrating epidemiological and evolutionary dynamics.

Structural and evolutionary insights into DAF-12 interactions with transcriptional coactivators in parasitic nematodes

This study investigates DAF-12 interactions with transcriptional coactivators in parasitic nematodes using structural and bioinformatic approaches, revealing conserved and nematode-specific mechanisms of coactivator recruitment.

Evaluating beta-tubulin variants as predictors of benzimidazole resistance across Caenorhabditis nematodes

The paper identifies beta-tubulin variants associated with benzimidazole resistance in three Caenorhabditis species and shows species-specific patterns of resistance.

Helminth infection dynamics in rehabilitating Javan slow lorises are driven by time since deworming rather than host traits

This study examines helminth infection dynamics in rehabilitating Javan slow lorises, finding that infection patterns are influenced by time since deworming rather than host traits or release readiness.

The development and validation of long-read ITS-1/5.8S/ITS-2 nemabiome metabarcoding using Oxford Nanopore Technologies (ONT) sequencing for ovine gastrointestinal nematodes and the design of primers suitable for its direct application to fecal DNA.

Evolution of ivermectin resistance in the nematode model Caenorhabditis elegans: critical influence of population size and unexpected cross-resistance to emodepside

This study shows that large population size accelerates ivermectin resistance in C. elegans, with unexpected cross-resistance to emodepside and sexual recombination playing a role.

Critical Role of P-Glycoprotein-9 in Ivermectin Tolerance in Nematodes

This study identifies P-glycoprotein-9 as a key mediator of ivermectin resistance in nematodes by showing its role in drug efflux and demonstrating functional conservation across species.

Prevalence and Associated Risk Factors of Bovine Fasciolosis in Bahir Dar, Ethiopia: Cross-Sectional Study

This study assesses the prevalence and risk factors of bovine fasciolosis in Bahir Dar, Ethiopia, finding a 49.21% prevalence rate with significant regional and body condition disparities.

Development of a qPCR assay and tremabiome deep amplicon sequencing method for differentiation of fluke species in livestock

This paper develops a qPCR assay and tremabiome deep amplicon sequencing method to improve fluke species identification in livestock, finding high co-infection rates and improved sensitivity compared to traditional methods.

Pseudocapillaria tomentosa Infections in Laboratory Larval and Adult Zebrafish (Danio rerio): Development and Advances in an In Vivo Anthelmintic Drug Discovery Model

This study develops a larval zebrafish model for anthelmintic drug discovery by validating it with emamectin benzoate and documenting the development of Pseudocapillaria tomentosa.

Polo-like kinase 1 regulates growth in juvenile Fasciola hepatica

This study identifies polo-like kinase 1 (fhplk1) as a key regulator of growth in juvenile Fasciola hepatica by showing its role in stem cell proliferation and cell cycle control.

Ambient temperature storage in DESS supports molecular studies of benzimidazole resistance from canine hookworm eggs

This study shows that DESS preserves canine faeces for molecular analysis without refrigeration, enabling reliable detection of hookworm species and resistance SNPs.

Transcriptional responses to in vitro macrocyclic lactone exposure in Toxocara canis larvae using RNA-seq

This study uses RNA-seq to analyze transcriptional changes in Toxocara canis larvae exposed to macrocyclic lactones, identifying differentially expressed genes and their biological implications.

Safety and Efficacy of a Novel Glycoengineered Recombinant Vaccine Candidate against Haemonchus contortus in Sheep

This study evaluates a glycoengineered vaccine against Haemonchus contortus in sheep, showing reduced worm burden and fecal egg shedding compared to non-glycoengineered and unvaccinated controls.

Characterisation of β-tubulin isotypes in Uncinaria stenocephala and implications for benzimidazole resistance in hookworms

This paper characterizes β-tubulin isotypes in Uncinaria stenocephala and confirms key benzimidazole-susceptible residues, enabling SNP screening for resistance.

GLOWORM-META: Modelling gastrointestinal nematode metapopulation dynamics to inform cattle biosecurity research

This paper develops a metapopulation model for cattle gastrointestinal nematodes to evaluate biosecurity measures and their impact on anthelmintic resistance.

Spatio-temporal diversity and genetic architecture of pyrantel resistance in Cylicocyclus nassatus, the most abundant horse parasite

The paper builds a reference genome for Cylicocyclus nassatus, estimates its genetic diversity across regions, and identifies genetic candidates for pyrantel resistance.

Hematobiochemical Alterations and Pathological Lesions Induced by Fasciolosis in Slaughtered Cattle at Gondar ELFORA Abattoir, Ethiopia

This study assesses hematobiochemical changes and pathological lesions in cattle with fasciolosis at an Ethiopian abattoir, finding significant differences between infected and non-infected animals.

Albendazole specifically disrupts microtubules and protein turnover in the tegument of the cestode Mesocestoides corti

This study shows albendazole disrupts microtubules and reduces protein turnover in the tegument of Mesocestoides corti, suggesting translational inhibition contributes to its anthelmintic effect.

Anthelmintic resistance against benzimidazoles and macrocyclic lactones in strongyle populations on cattle farms in northern Germany

The paper assesses anthelmintic resistance in cattle nematodes, finding widespread resistance to both benzimidazoles and macrocyclic lactones and highlighting the need for sustainable treatment strategies.

Larval motility assay using WMicrotracker: a high throughput test to discriminate between resistance and susceptibility to anthelmintic drugs in nematodes

The paper introduces a high-throughput motility assay using WMicrotracker to detect anthelmintic resistance in nematodes, showing it can distinguish between susceptible and resistant strains.

GI-NemaTracker - A farm system-level mathematical model to predict the consequences of gastrointestinal parasite control strategies in sheep

The paper presents a systems-level mathematical model to predict the effects of gastrointestinal parasite control strategies in sheep, showing that similar flock weights can be achieved with fewer treatments.

Chromosomal genome assembly resolves drug resistance loci in the parasitic nematode Teladorsagia circumcincta

The paper generates a chromosome-scale genome assembly for Teladorsagia circumcincta and identifies genetic loci associated with drug resistance to improve anthelmintic resistance diagnostics.

Haematobiochemical Alterations and Lesion Characterization Induced by Haemonchosis in Sheep Slaughtered at Gondar ELFORA Abattoir, North West Ethiopia

This study examines hematobiochemical changes and lesion characteristics in sheep with haemonchosis, finding significant anemia and protein loss, and recommends protein supplementation for infected animals.

A new class of natural anthelmintics targeting lipid metabolism

This study identifies avocado fatty alcohols/acetates (AFAs) as a new class of anthelmintics that target lipid metabolism in parasitic nematodes.

Widespread occurrence of benzimidazole resistance single nucleotide polymorphisms in the canine hookworm, Ancylostoma caninum, in Australia

This study identifies widespread benzimidazole resistance in Ancylostoma caninum in Australia through genetic analysis and egg hatch assays.

Exploitation of phylum-spanning omics resources reveals complexity in the nematode FLP signalling system and provides insights into flp-gene evolution

This study identifies 2143 flp-genes across 100+ nematode species, revealing evolutionary patterns and expression dynamics of FLPs in parasitic nematodes.

High-throughput screening of more than 30,000 compounds for anthelmintics against gastrointestinal nematode parasites

This study screens over 30,000 compounds to identify new anthelmintics effective against gastrointestinal nematodes, finding 55 compounds with broad-spectrum activity.

Prevalence of GIT nematodes and associated risk factors of exotic chickens in selected farm of poultry in and around Ambo, Ethiopia

The study estimates GI nematode prevalence in chickens in Ethiopia and identifies risk factors like body condition, location, and sex.