Helminth infection and control

Green synthesis of silver nanoparticles from Artemisia afra and Artemisia annua leaf extracts: Enhanced in vitro anthelmintic activity against Haemonchus contortus

This paper evaluates green-synthesized silver nanoparticles from Artemisia species for in vitro anthelmintic activity against Haemonchus contortus, showing superior efficacy compared to a commercial drug.

Protein expression of short-chain dehydrogenases/reductases and their inducibility by flubendazole in Haemonchus contortus

The paper investigates SDR gene and protein expression in H. contortus, finding sex- and strain-specific differences and FLU-induced changes in resistant strains.

Evaluation of ivermectin effectiveness under contrasting anthelmintic resistance scenarios in beef cattle: a comparative study in Italy and Argentina

This study evaluates ivermectin efficacy in beef cattle in Italy and Argentina, finding high efficacy in Italy but resistance in Argentina.

Sex-biased transcriptional rewiring of neuronal circuits associated with eprinomectin resistance in Haemonchus contortus

The paper identifies sex-biased transcriptional changes and genetic loci associated with eprinomectin resistance in Haemonchus contortus using genomic and transcriptomic analyses.

Comparative genomic and transcriptomic analyses of Strongylus vulgaris reveal developmental and evolutionary deployment of parasitism in a migratory equine nematode

This paper presents a genomic and transcriptomic analysis of Strongylus vulgaris, revealing developmental and evolutionary aspects of its parasitic lifestyle and identifying key genes and isoforms involved in its biology.

Nutritional Anthelmintics: Chicory Reconfigures the Equine Holobiont Across Microbial, Parasitic, and Host Scales

This study shows that chicory reduces cyathostomin parasites and alters gut microbiota in horses without affecting host physiology.

Development and validation of a multilocus sequence typing scheme for Fasciola hepatica using next-generation deep amplicon sequencing

The paper develops and validates a multilocus sequence typing scheme for Fasciola hepatica using next-generation sequencing to study population genetic structure across UK cattle and sheep populations.

Limited genetic structure and high gene flow in Fasciola hepatica populations infecting ruminants in different geographic areas in the UK

This study analyzes genetic structure in Fasciola hepatica populations across UK ruminants using mt-ND1 and mt-COX1 loci, finding limited genetic structure and high gene flow.

A Comprehensive epidemiological and molecular study of gastrointestinal helminths of Companion Animals in Northeastern Bangladesh: A neglected zoonotic threat

This study examines gastrointestinal helminths in companion animals in northeastern Bangladesh, finding high prevalence and zoonotic potential, with stray animals and poor deworming as key risk factors.

Novel integrated risk index reveals uneven impact of climate change on fascioliasis risk across Africa and Europe

This paper develops a novel risk index to predict how climate change will affect fascioliasis transmission risk across Africa and Europe, finding that risk will generally decrease but with geographic variation.

Immune Signatures of Gastrointestinal Helminth Infection in Transcriptomes of European Bison

The paper analyzes transcriptomes of European bison to identify immune responses to gastrointestinal nematode infection, finding no significant gene expression changes with parasite burden but enriched immune-related pathways.

The Dirofilaria immitis unc-49 gene encodes a pharmacologically unique cys-loop GABA receptor

This study identifies and characterizes two unc-49 subunits from Dirofilaria immitis, revealing unique pharmacological properties of their GABA receptors.

Modulation of serotonergic, dopaminergic and tubulin-associated pathways by tannin-free natural products in Caenorhabditis elegans reveals effective anthelmintic drug targets

This study evaluates the anthelmintic effects of 19 tannin-free natural products on C. elegans, identifying gene targets involved in neurotransmission and development.

Serotonin signaling modulates growth and motility in juvenile Fasciola hepatica

This paper investigates the role of serotonin signaling in juvenile Fasciola hepatica, showing it modulates motility and growth through specific receptor mechanisms.

Characterising anthelmintic resistance against benzimidazoles and macrocyclic lactones in gastrointestinal nematode populations of dairy cattle

This study assesses anthelmintic resistance in cattle nematodes using FECRT and molecular methods, finding high resistance allele frequencies and multidrug resistance in Scottish populations.

Copy number variations in mitochondrial DNA has a potent role in parasitic immunity against Haemonchus contortus-A novel report

The paper reports that lower mitochondrial DNA copy numbers in sheep are associated with increased susceptibility to Haemonchus contortus infection, suggesting a role for mtDNA in parasitic immunity.

Survey of benzimidazole resistance in ascarid parasites of poultry

This study tests fenbendazole efficacy against ascarid parasites in poultry, finding resistance in one Ascaridia galli isolate and all Heterakis gallinarum isolates.

Beyond Motility: A Multiparametric Fitness Assay Framework to Evaluate Anthelmintics in Nippostrongylus brasiliensis

The paper develops a multiparametric fitness assay to evaluate anthelmintics in Nippostrongylus brasiliensis, finding that NCR247 does not significantly impair parasite fitness across tested parameters.

Unveiling mode of action of anthelmintics in Caenorhabditis elegans with SydLab™, an on-a-chip automated and high-content screening system.

This study evaluates eight anthelmintic compounds in C. elegans using SydLab, identifying drug-specific phenotypes and modes of action through automated imaging and machine learning.

Cytochrome c oxidase I deep amplicon sequencing for metabarcoding of equine strongyle communities: unexpectedly high Strongylus spp. burden in treated horses

This study uses COI metabarcoding to analyze strongyle communities in treated and untreated equines, finding that deworming treatments influence species composition but not diversity, with Strongylus spp. more prevalent in untreated groups.

Prevalence and risk factors of ovine and caprine fasciolosis in Ethiopia: a systematic review and meta-analysis

This study conducts a systematic review and meta-analysis to estimate the prevalence and risk factors of fasciolosis in Ethiopian small ruminants, finding a pooled prevalence of 32.25% with high heterogeneity.

UBR-1 deficiency leads to ivermectin resistance in C. elegans

This study shows that UBR-1 deficiency in C. elegans causes ivermectin resistance by disrupting glutamate signaling and GluCl function.

Naturally occurring variation in a cytochrome P450 modifies thiabendazole responses independent of beta-tubulin

This paper identifies a cytochrome P450 gene variant that contributes to benzimidazole resistance in nematodes, independent of beta-tubulin mutations.

Investigation of risk factors associated with Ancylostoma spp. infection and the benzimidazole F167Y resistance marker polymorphism in dogs from the United States

The paper investigates risk factors for Ancylostoma spp. infection and the F167Y resistance marker in US dogs using molecular diagnostics and qPCR.

Wnt/β-catenin signalling underpins juvenile Fasciola hepatica growth and development

This study identifies Wnt/β-catenin signaling as critical for juvenile Fasciola hepatica growth and development, with pharmacological inhibition showing potential for novel therapeutic strategies.

Quantitative tests of albendazole resistance in beta-tubulin mutants

The paper tests the role of five beta-tubulin genes in benzimidazole resistance in C. elegans, finding that only ben-1 loss confers substantial resistance.

Single-cell transcriptomics identifies a p21-activated kinase important for survival of the zoonotic parasite Fasciola hepatica

The paper uses scRNA-seq to analyze Fasciola hepatica cells, identifies new cell types and gene expression patterns, and highlights PAK4's role in parasite survival.

Moonlighting on the Fasciola hepatica tegument: enolase, a glycolytic enzyme, interacts with the extracellular matrix and fibrinolytic system of the host

This study characterizes enolase from Fasciola hepatica as a moonlighting protein that binds host extracellular matrix and fibrinolytic components, aiding parasite invasion and migration.

Neoblast-like Stem Cells of Fasciola hepatica

This paper identifies and characterizes neoblast-like stem cells in Fasciola hepatica, showing their self-renewal, differentiation, and radiation sensitivity, and identifies potential drug targets.

Spatial transcriptomics of a parasitic flatworm provides a molecular map of vaccine candidates, drug targets and drug resistance genes

The paper presents the first spatial transcriptome of the liver fluke Fasciola hepatica, identifying gene expression profiles and markers for eight tissues, with focus on vaccine candidates, drug targets, and resistance genes.