Mast cells and histamine

Treatment with carnosic acid attenuates the secretion of pro-inflammatory mast cell mediators following IL-33 activation

This study shows carnosic acid reduces pro-inflammatory mediator release from mast cells after IL-33 activation, despite increasing intracellular levels of these mediators.

FosB/ΔFosB activation in mast cells regulates gene expression to modulate allergic inflammation in male mice

This study shows that FosB/ΔFosB in mast cells regulates gene expression to reduce allergic inflammation in male mice by enhancing DUSP4 expression.

Protective role of protease-activated receptor-2 in anaphylaxis model mice

This study investigates the role of PAR-2 in anaphylaxis using PAR-2-deficient and tryptase-deficient mice, finding that PAR-2 protects against anaphylaxis by modulating eNOS activity.

Genetically determining individualized clinical reference ranges for the biomarker tryptase can limit unnecessary procedures and unmask myeloid neoplasms

This study determines individualized tryptase reference ranges by modeling BST levels based on TPSAB1 copy number, showing that elevated levels can indicate clonal myeloid neoplasms or be normal in HT carriers.

Genetic Analysis of Bphse: a Novel Gene Complementing Resistance to Bordetella pertussis-Induced Histamine Sensitization

The paper identifies a genetic modifier locus, Bphse, that complements resistance to histamine sensitization in mice by analyzing Hrh1 alleles and using network-based methods.

GATA2 regulates mast cell identity and responsiveness to antigenic stimulation by promoting chromatin remodeling at super-enhancers

This study shows GATA2 regulates mast cell identity and antigen responsiveness by enhancing chromatin accessibility at super-enhancers.