Mast cells and histamine

A pathway to next-generation mast cell stabilizers identified through the novel Phytomedical Analytics for Research Optimization at Scale data platform.

This study identifies potential next-generation mast cell stabilizers using a novel data platform and in vitro pharmacology, prioritizing candidates from phytomedicine.

Sennoside A differentially regulates mast cell activation and attenuates gut allergic inflammation

This study shows sennoside A modulates mast cell activation differently under resting and allergic conditions, reducing allergic inflammation in a mouse model of food allergy.

Mast cells initiate lymphocyte egress from distant lymph nodes upon skin inflammation via a RANKL-sphingosine-1-phosphate axis

This study shows that mast cells use a RANKL-S1P axis to control lymphocyte egress from distant lymph nodes during skin inflammation.

PDE3A-SLFN12 Molecular Glues Target Multiple KIT D816V Cell Types in Preclinical Models of Mast Cell Malignancies

This paper identifies PDE3A-SLFN12 molecular glues as a novel therapeutic target for KIT D816V-driven mast cell malignancies, showing their efficacy in killing multiple KIT D816V cell types and synergy with tyrosine kinase inhibitors.

Medical-Grade Manuka Honey and Manuka Honey Extract Inhibit Mast Cell Degranulation through inhibition of MRGPRX2 expression: Potential Intravesical Agent for the Management of Interstitial Cystitis/Bladder Pain Syndrome?

This study shows that Medihoney and a sugar-free Manuka honey extract inhibit Substance P-induced mast cell degranulation by suppressing MRGPRX2 activation, suggesting their potential as therapies for IC/BPS.

Medical Grade Manuka Honey Inhibits A23187 Induced Mast Cell Degranulation and Cytokine Release via Downregulation of the ERK Signalling Pathways

This study shows Medical Grade Manuka Honey inhibits A23187-induced mast cell degranulation and cytokine release by downregulating ERK1/2 signaling.

IgE occupancy and antigen valency cooperate to control FcϵRI aggregation geometry and signaling efficiency

This study shows that allergen valency and epitope arrangement influence FcϵRI aggregation and signaling in mast cells.

Mast Cell Specific Cyp11a1 Deficiency Promotes T Cell Mediated Immunity and Suppresses Tumour Metastasis in a Mouse Model of Melanoma

This study shows that mast cell-specific Cyp11a1 deficiency reduces melanoma metastasis by enhancing T cell immunity and suppressing mast cell-derived steroid effects.

p38 dependent IL-33 responses define a conserved inflammatory programme in mast cells

This study compares IL-33-induced proteomic responses across different mast cell types and identifies p38 MAPK as a key regulator of the inflammatory programme.

Role of the IRE1α-XBP1 axis in IgE-dependent activation of mast cells

This study investigates the role of the IRE1α-XBP1 axis in IgE-dependent mast cell activation and finds it is critical for degranulation and cytokine release in allergic responses.

Anchored for action: a dual role for integrin β1 in mast cell perivascular positioning and vasoactivity to license leukocyte recruitment

This study shows that integrin β1 is essential for mast cell positioning around arterioles and their vasoactive function, which are critical for leukocyte recruitment during inflammation.

Loss of Mast cells and histaminergic signaling link diet to platelet-mediated NETosis and mammary cancer recurrence

This study links diet to mammary cancer recurrence via mast cell loss and histaminergic signaling, showing that H2R antagonists promote platelet-mediated NETosis and reemergence from dormancy.

Mast cell desensitization induces a distinct IgE-dependent transcriptional program associated with immune regulation

This study identifies a distinct transcriptional program in mast cells during desensitization, showing it involves active reprogramming rather than passive hyporesponsiveness.

Adenosine-specific transcriptional programs in murine connective tissue type mast cells

The paper identifies adenosine-specific gene programs in murine mast cells through bulk RNA-Seq, revealing novel mediators and pathways involved in adenosine-evoked inflammation.

Tumor Microenvironmental Interactions of Mast Cells and Lymphocytes in Gastric Cancer: A Tissue-Based Study

This study examines mast cell and CD8+ TIL densities in gastric adenocarcinoma and finds their significant correlation with tumor grades.

Mast cell extracellular granules are bioactive condensates driven by heparin and polyamine

This study identifies mast cell extracellular granules as bioactive condensates formed by heparin and polyamines, enhancing enzymatic activity and cytokine bioactivity.

AXL mediates mast cell survival and resistance to tyrosine kinase inhibitors in mastocytosis

This study identifies AXL as a driver of mast cell survival and TKI resistance in mastocytosis and shows that dual KIT/AXL inhibition restores TKI sensitivity.

Mast cells interact directly with colorectal cancer cells to promote epithelial-to-mesenchymal transition

This study shows mast cells promote epithelial-to-mesenchymal transition in colorectal cancer through direct contact and integrin-mediated signaling.

Modulation of hippocampal synaptic transmission by mast cells at the hippocampal-thalamic border during early brain development

The paper investigates the role of mast cells in modulating hippocampal synaptic transmission at the hippocampal-thalamic border during early brain development in mice.

Mast cells are not essential for pubertal mammary gland branching.

This study shows that mast cells are not essential for pubertal mammary gland branching in mice, using multiple genetic models.

Developmental PBDE exposure impairs histamine release from mast cells by altering granule maturation and calcium signaling in adult male and female mice

This study shows developmental PBDE exposure impairs mast cell function in adult mice by disrupting granule maturation and calcium signaling, leading to reduced histamine release.

Epithelial tumor cells utilize mast cell-derived histamine to regulate perineural invasion

This study identifies mast cell-derived histamine as a regulator of perineural invasion in epithelial cancers, showing that H1-antihistamines improve survival and immunotherapy response.

The role of GATA2 in the expression of the soluble decoy receptor ST2/IL1RL1 in human and mouse mast cells

This study identifies GATA2 as a key regulator of sST2 expression in mast cells through chromosomal conformational changes.

Embryonic Mast Cells Arise from Cpa3-expressing Precursors Independent of Granulocyte-Monocyte Progenitors

This study identifies Cpa3-expressing precursors as the source of embryonic mast cells, independent of granulocyte-monocyte progenitors, using single-cell RNA sequencing and genetic fate mapping.

PU.1 and TGF-β signaling transactivate CD103 expression in mast cells and dendritic cells: Opposite roles of GATA2 in the expression of mucosal mast cell-specific genes

The paper investigates the transcriptional regulation of CD103 in mast cells and dendritic cells, showing that PU.1 transactivates CD103 expression while GATA2 represses it.

Primitive steroidogenesis in mast cells: A novel regulatory mechanism for mast cell function

This study identifies de novo steroidogenesis in mast cells as a novel regulatory mechanism essential for their development, survival, and function, with implications for inflammatory and anaphylactic responses.

Melanoma cells suppress mast cell growth via a melanin-dependent mechanism

This study shows melanoma cells inhibit mast cell growth through melanin, which induces apoptosis and impairs activation by affecting nuclear morphology and histone 3.

Combined in vitro differentiation and cell sorting-based isolation of highly pure mouse bone marrow-derived basophils.

This study develops an in vitro differentiation and cell sorting method to isolate highly pure mouse basophils (>98%) that maintain lineage markers and functional responses.

Antimicrobial cetylpyridinium chloride suppresses mast cell function by targeting tyrosine phosphorylation of Syk kinase

This study shows that cetylpyridinium chloride inhibits mast cell function by disrupting tyrosine phosphorylation of Syk kinase and LAT, without affecting Lyn kinase.

Single cell transcriptomics reveal mast cell heterogeneity in the human gut

The paper uses single-cell RNA sequencing to identify five distinct mast cell subsets in the human colon, revealing layer-specific distribution and functional profiles.