Mast cells and histamine

A pathway to next-generation mast cell stabilizers identified through the novel Phytomedical Analytics for Research Optimization at Scale data platform.

This study identifies potential next-generation mast cell stabilizers using a novel data platform and in vitro pharmacology, prioritizing candidates from phytomedicine.

Mast cells initiate lymphocyte egress from distant lymph nodes upon skin inflammation via a RANKL-sphingosine-1-phosphate axis

This study shows that mast cells use a RANKL-S1P axis to control lymphocyte egress from distant lymph nodes during skin inflammation.

IgE occupancy and antigen valency cooperate to control FcϵRI aggregation geometry and signaling efficiency

This study shows that allergen valency and epitope arrangement influence FcϵRI aggregation and signaling in mast cells.

Mast Cell Specific Cyp11a1 Deficiency Promotes T Cell Mediated Immunity and Suppresses Tumour Metastasis in a Mouse Model of Melanoma

This study shows that mast cell-specific Cyp11a1 deficiency reduces melanoma metastasis by enhancing T cell immunity and suppressing mast cell-derived steroid effects.

Role of the IRE1α-XBP1 axis in IgE-dependent activation of mast cells

This study investigates the role of the IRE1α-XBP1 axis in IgE-dependent mast cell activation and finds it is critical for degranulation and cytokine release in allergic responses.

Adenosine-specific transcriptional programs in murine connective tissue type mast cells

The paper identifies adenosine-specific gene programs in murine mast cells through bulk RNA-Seq, revealing novel mediators and pathways involved in adenosine-evoked inflammation.

Tumor Microenvironmental Interactions of Mast Cells and Lymphocytes in Gastric Cancer: A Tissue-Based Study

This study examines mast cell and CD8+ TIL densities in gastric adenocarcinoma and finds their significant correlation with tumor grades.

Mast cells interact directly with colorectal cancer cells to promote epithelial-to-mesenchymal transition

This study shows mast cells promote epithelial-to-mesenchymal transition in colorectal cancer through direct contact and integrin-mediated signaling.

Mast cells are not essential for pubertal mammary gland branching.

This study shows that mast cells are not essential for pubertal mammary gland branching in mice, using multiple genetic models.

The role of GATA2 in the expression of the soluble decoy receptor ST2/IL1RL1 in human and mouse mast cells

This study identifies GATA2 as a key regulator of sST2 expression in mast cells through chromosomal conformational changes.

Embryonic Mast Cells Arise from Cpa3-expressing Precursors Independent of Granulocyte-Monocyte Progenitors

This study identifies Cpa3-expressing precursors as the source of embryonic mast cells, independent of granulocyte-monocyte progenitors, using single-cell RNA sequencing and genetic fate mapping.

Combined in vitro differentiation and cell sorting-based isolation of highly pure mouse bone marrow-derived basophils.

This study develops an in vitro differentiation and cell sorting method to isolate highly pure mouse basophils (>98%) that maintain lineage markers and functional responses.

Antimicrobial cetylpyridinium chloride suppresses mast cell function by targeting tyrosine phosphorylation of Syk kinase

This study shows that cetylpyridinium chloride inhibits mast cell function by disrupting tyrosine phosphorylation of Syk kinase and LAT, without affecting Lyn kinase.

Protective role of protease-activated receptor-2 in anaphylaxis model mice

This study investigates the role of PAR-2 in anaphylaxis using PAR-2-deficient and tryptase-deficient mice, finding that PAR-2 protects against anaphylaxis by modulating eNOS activity.

Genetically determining individualized clinical reference ranges for the biomarker tryptase can limit unnecessary procedures and unmask myeloid neoplasms

This study determines individualized tryptase reference ranges by modeling BST levels based on TPSAB1 copy number, showing that elevated levels can indicate clonal myeloid neoplasms or be normal in HT carriers.

GATA2 regulates mast cell identity and responsiveness to antigenic stimulation by promoting chromatin remodeling at super-enhancers

This study shows GATA2 regulates mast cell identity and antigen responsiveness by enhancing chromatin accessibility at super-enhancers.