Optical Coherence Tomography Applications

Effectiveness of Digital Dispersion Compensation in OCT

This study compares physical and digital dispersion compensation in OCT, finding that digital methods can restore sensitivity but fail beyond a dispersion mismatch threshold.

Freeform robotic optical coherence tomography beyond the optical field-of-view limit

This paper introduces a freeform robotic OCT system to overcome the FOV limitation in imaging non-planar anatomies, demonstrating its application in imaging the mouse eye's aqueous humor outflow pathway.

Insight into human photoreceptor function: modeling optoretinographic responses to diverse stimuli

The paper introduces an optoretinographic imaging platform to measure human retinal neuron responses to diverse stimuli and proposes a model to predict these responses.

Application of Spectral Domain Optical Coherence Tomography To Guide Cochlear Implant Electrode Array

This paper demonstrates a custom SD-OCT system for real-time guidance of cochlear implant electrode arrays in mice and cadaveric human temporal bones.

Retinal thermometry in-vivo using phase-sensitive optical coherence tomography

This paper demonstrates a method to measure retinal temperature rise in vivo using phase-sensitive OCT, showing differences in thermal deformation between healthy and degenerate retinas.

Combined optical coherence tomography and electroretinography (OCT+ERG) system for imaging neurovascular coupling in the human retina

The paper develops an OCT+ERG system to image neurovascular coupling in the human retina and shows correlated neuronal and blood flow responses to visual stimuli.

Gold Nanocages as Scattering Contrast Agents for Optical Coherence Tomography

This study introduces gold nanocages as scattering-dominant contrast agents for OCT, showing enhanced imaging contrast in tissue phantoms, ex vivo, and in vivo models.

Gold Nanocages with a Long SPR Peak Wavelength as Contrast Agents for Optical Coherence Tomography Imaging at 1060 nm

This study develops gold nanocages with a surface plasmon resonance peak at 1060 nm as contrast agents for OCT imaging, showing enhanced imaging contrast in phantoms and mouse tissues.

Optical coherence tomography enables longitudinal evaluation of cell graft-directed remodeling in stroke lesions

This study uses OCT to track changes in stroke lesions after cell grafting, finding that lesion contraction and graft survival are influenced by lesion size and severity.

Effective Multiple Scattering Correction for Accurate Quantitative OCT

This paper develops a method to correct multiple scattering in qOCT to improve tissue attenuation coefficient accuracy, validated with phantoms and simulations.

Imaging of developing human brains with ex vivo PSOCT and dMRI

This study uses PSOCT and ex vivo dMRI to image developing human brains, showing PSOCT's ability to quantify myelination and fiber orientation with micrometer resolution.

Optical Clearing with Tartrazine Enables Deep Transscleral Imaging with Optical Coherence Tomography

This paper demonstrates that tartrazine improves OCT imaging of the suprachoroidal space by reducing light scattering in ex vivo eye models.

Non-destructive viability assessment of cancer cell spheroids using dynamic optical coherence tomography with trypan blue validation

This study validates dynamic optical coherence tomography as a quantitative viability assessment tool for 3D cancer cell spheroids using trypan blue exclusion as a reference.

Multi-Scale Label-free Human Brain Imaging with Integrated Serial Sectioning Polarization Sensitive Optical Coherence Tomography and Two-Photon Microscopy

This paper introduces a multi-scale imaging technique combining PSOCT and 2PM to enable label-free, high-resolution analysis of human brain structure and pathology.

Quantitative imaging of three-dimensional fiber orientation in the human brain via two illumination angles using polarization-sensitive optical coherence tomography

This paper introduces a method to measure 3D fiber orientation in the human brain using two illumination angles in PS-OCT, achieving high angular precision and detailed 3D maps.

Characterizing Cone Spectral Classification by Optoretinography

This study compares optoretinography (ORG) and retinal densitometry for cone spectral classification, finding ORG offers higher sensitivity and reliability.

Velocity-based optoretinography for clinical applications

This paper introduces a velocity-based optoretinography method that measures subcellular retinal feature movement, demonstrating reproducibility and dose/retinal eccentricity dependence in healthy subjects.

Scalable mapping of myelin and neuron density in the human brain with micrometer resolution

This paper quantifies myelin content and neuron density in the human brain using OCT, finding a strong linear relationship between scattering coefficient and myelin content.

Quantification of volumetric morphometry and optical property in the cortex of human cerebellum at micrometer resolution

This study quantifies volumetric morphometry and optical properties of human cerebellar cortex at micrometer resolution using as-PSOCT, revealing layer-specific variations and cross-subject variability.

Capillary stall quantification from optical coherence tomography angiogram maximum intensity projections

The paper introduces a method to quantify transient capillary stalls in OCT angiograms using maximum intensity projections and provides open-source code for reproducible research.

A novel algorithm to optimize generalized gamma distributed multiplicative noise with implications on speckle removal from OCT images

This paper introduces an algorithm to optimize generalized gamma distributed multiplicative noise in OCT images, improving speckle removal and contrast-to-noise ratio.

The optoretinogram reveals how human photoreceptors deform in response to light

This paper introduces optoretinogram, a non-invasive method to image light-induced shape changes in human cone photoreceptors in vivo, revealing a biphasic response to light.