Jean C. Augustinack

The modular nature of long-association pathways in the human brain

Diffusion MRI tractography below 750 µm resolves the dorsal superior longitudinal fasciculus into layered fiber systems of varying length, matching macaque tracing; 1.5 mm tractography misses this.

The Infant Brainstem - A Multimodal Multiscale Postmortem Imaging Pipeline

This paper introduces a postmortem imaging pipeline for infant brainstem analysis, combining multiple modalities to overcome MRI limitations and enable high-resolution 3D visualization.

Hierarchical X-ray microscopy and mesoscopic diffusion MRI in the same brain reveal the human connectome across scales

The paper presents a multimodal imaging pipeline that combines diffusion MRI and high-resolution X-ray microscopy to map the human connectome across multiple scales.

A human subcortical connectome at 400 μm resolution

This paper presents the first extensive reconstruction of human subcortical fiber pathways using ultra-high-resolution dMRI, providing a high-definition atlas with clinical applications.

Multi-dimensional diffusion MRI at ultra-high gradient strength for mapping axonal architecture and microstructure in the primate brain

This paper presents high-resolution diffusion MRI data from macaque and human brains, enabling detailed mapping of axonal architecture and microstructure.

Harmonized Protocol for Subfield Segmentation in the Hippocampal Body on High-Resolution in vivo MRI from the Hippocampal Subfields Group (HSG)

The paper develops a harmonized segmentation protocol for hippocampal subfields in MRI, improving cross-study comparisons and understanding of subfield structure and function.

Fast segmentation with the NextBrain histological atlas

The paper introduces a fast segmentation tool for brain MRI scans using a hybrid method, achieving comparable accuracy to a Bayesian approach but with significantly reduced runtime.

Tentorium cerebelli notch severity in the human brain: protocol, distribution and histopathology validation

The paper develops a protocol to assess tentorial notch severity in the entorhinal cortex using postmortem samples and finds a positive correlation between TN severity and penumbra scores.

Automatic Geometry-based Estimation of the Locus Coeruleus Region on T1-Weighted Magnetic Resonance Images

This paper evaluates two methods for automatically estimating the locus coeruleus region from standard T1-weighted MRI scans using non-contrast neuroanatomical data.

Comparison of histological delineations of medial temporal lobe cortices by four independent neuroanatomy laboratories

This paper compares cytoarchitectonic delineations of medial temporal lobe subregions by four neuroanatomists, finding higher agreement in some areas and less in others.

A next-generation, histological atlas of the human brain and its application to automated brain MRI segmentation

The paper introduces NextBrain, a probabilistic histological atlas of the human brain, and presents a tool for automated MRI segmentation of anatomical regions.

Segmentation of supragranular and infragranular layers in ultra-high resolution 7T ex vivo MRI of the human cerebral cortex

This paper introduces a semi-supervised segmentation model for identifying supragranular and infragranular layers in human cerebral cortex MRI scans with high precision.

Multi-Scale Label-free Human Brain Imaging with Integrated Serial Sectioning Polarization Sensitive Optical Coherence Tomography and Two-Photon Microscopy

This paper introduces a multi-scale imaging technique combining PSOCT and 2PM to enable label-free, high-resolution analysis of human brain structure and pathology.

Quantitative imaging of three-dimensional fiber orientation in the human brain via two illumination angles using polarization-sensitive optical coherence tomography

This paper introduces a method to measure 3D fiber orientation in the human brain using two illumination angles in PS-OCT, achieving high angular precision and detailed 3D maps.

Sustaining wakefulness: Brainstem connectivity in human consciousness

The paper maps brainstem connections sustaining wakefulness using ex vivo diffusion MRI, immunohistochemistry, and in vivo 7 Tesla functional MRI.

Scalable mapping of myelin and neuron density in the human brain with micrometer resolution

This paper quantifies myelin content and neuron density in the human brain using OCT, finding a strong linear relationship between scattering coefficient and myelin content.

A multimodal imaging and analysis pipeline for creating a cellular census of the human cerebral cortex

The paper develops an imaging pipeline to create a cell census of the human cerebral cortex using MRI, immunohistochemistry, and light-sheet fluorescence microscopy.

High-fidelity approximation of grid- and shell-based sampling schemes from undersampled DSI using compressed sensing: Post mortem validation

This study validates compressed sensing for DSI reconstruction, showing high fidelity at R=3 with reduced acquisition time, but degradation at higher acceleration factors.

Conductance-Based Structural Brain Connectivity in Aging and Dementia

This paper quantifies structural brain connectivity using diffusion MRI in aging and dementia, finding age-related trends and regional effects that suggest potential for age prediction and studying structural connections.

Probabilistic atlas of the lateral parabrachial nucleus, medial parabrachial nucleus, vestibular nuclei complex and medullary viscero-sensory-motor nuclei complex in living humans from 7 Tesla MRI

The paper creates a probabilistic brainstem atlas in living humans using 7 Tesla MRI to improve the localization of key nuclei for autonomic and sensory-motor functions.

7 Tesla MRI of the ex vivo human brain at 100 micron resolution

The paper presents an ultra-high resolution MRI dataset of an ex vivo human brain and provides it in both native and stereotactic spaces for research and educational use.